Annals of Surgical Oncology

, Volume 22, Issue 1, pp 203–208 | Cite as

Diagnostic Performance of Multidetector Row Computed Tomography for Assessment of Lymph Node Metastasis in Patients with Distal Rectal Cancer

  • Hirotoshi Kobayashi
  • Akifumi Kikuchi
  • Satoshi Okazaki
  • Megumi Ishiguro
  • Toshiaki Ishikawa
  • Satoru Iida
  • Hiroyuki Uetake
  • Kenichi Sugihara
Colorectal Cancer

Abstract

Background

The accurate preoperative diagnosis of depth of tumor invasion and nodal status in distal rectal cancer is important because neoadjuvant chemotherapy or lateral pelvic lymph node dissection is indicated for patients with T3–T4 tumor or nodal involvement. This study aimed to determine the optimal cutoff value for predicting lymph node metastasis in patients with distal rectal cancer using multidetector row computed tomography (MDCT).

Methods

The study investigated 77 patients who had undergone surgery for distal rectal cancer at a single institution between 2008 and 2011. Diagnostic performance for depth of tumor invasion and mesorectal and lateral pelvic lymph node metastases was evaluated. The optimal cutoff value was determined by receiver operating characteristic curve analysis.

Results

For predicting mesorectal and lateral pelvic lymph node metastasis, MDCT had a sensitivity of 0.36 and 0.89 and a specificity of 0.78 and 0.97, respectively. The optimal cutoff values of major and minor axes lengths for predicting mesorectal lymph node metastasis were 6.5 mm and 5.7 mm, respectively. The areas under the curve (AUCs) were 0.82 and 0.88, respectively. For predicting lateral lymph node metastasis, the optimal cutoff values were 9 mm for the major axis and 6 mm for the minor axis. Both AUCs were 1.

Conclusions

Using MDCT, the optimal cutoff value of minor axis length for predicting mesorectal and lateral pelvic lymph node metastases in patients with distal rectal cancer was 6 mm. The accuracy of MDCT was satisfactory for predicting lateral pelvic lymph node metastasis.

Keywords

Total Mesorectal Excision Minor Axis Optimal Cutoff Preoperative Chemoradiotherapy Lateral Lymph Node Metastasis 

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Copyright information

© Society of Surgical Oncology 2014

Authors and Affiliations

  • Hirotoshi Kobayashi
    • 1
  • Akifumi Kikuchi
    • 2
  • Satoshi Okazaki
    • 2
  • Megumi Ishiguro
    • 3
  • Toshiaki Ishikawa
    • 2
  • Satoru Iida
    • 2
  • Hiroyuki Uetake
    • 3
  • Kenichi Sugihara
    • 2
  1. 1.Center for Minimally Invasive SurgeryTokyo Medical and Dental UniversityTokyoJapan
  2. 2.Department of Surgical Oncology, Graduate SchoolTokyo Medical and Dental UniversityTokyoJapan
  3. 3.Department of Translational OncologyTokyo Medical and Dental UniversityTokyoJapan

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