Annals of Surgical Oncology

, Volume 21, Issue 11, pp 3621–3627 | Cite as

Survival Benefit of Hyperthermic Intraperitoneal Chemotherapy for Recurrent Ovarian Cancer: A Multi-institutional Case Control Study

  • Jean-François Le Brun
  • Loic Campion
  • Dominique Berton-Rigaud
  • Gérard Lorimier
  • Frédéric Marchal
  • Gwenael Ferron
  • Anne Sophie Oger
  • François Dravet
  • Isabelle Jaffre
  • Jean-Marc Classe
Gynecologic Oncology



Hyperthermic intraperitoneal chemotherapy (HIPEC) and complete surgical removal of the tumor, in relapsing patients may provide a clinical benefit. There is no consensus considering the place of HIPEC for patients who had first ovarian cancer relapse. To assess for possible efficacy of HIPEC on overall survival (OS) rates in this situation, we performed a multi-institutional study.


The current study was a retrospective case control multi-institutional study comparing a group of patients treated with HIPEC to a group of patients treated without HIPEC. Inclusion criteria were first relapse of a serous ovarian carcinoma and >6 months after the end of initial treatment. Exclusion criteria were another pathological subtype of ovarian cancer, a relapse at <6 months after initial treatment, and a second relapse or more. We aimed to assess OS, morbidity, and mortality rates and prognostic factors.


From June 1997–July 2011, 42 patients were included, 23 in the HIPEC group and 19 in the control group. Each patient from the two groups had a complete secondary surgery at the time of the first relapse. At 4 years OS was 75.6 % in the HIPEC group and 19.4 % in the control group (p = 0.013). In a multivariate analysis, HIPEC and interval-free before the end of initial treatment were both independent prognostic factors.


When compared to the control group, complete secondary surgery and HIPEC appear to afford a better OS rate than complete secondary surgery alone, in case of first ovarian cancer relapse. Further randomized trials are warranted to confirm these results.


Overall Survival Ovarian Cancer Intraperitoneal Chemotherapy Peritoneal Cancer Index Gynecologic Oncology Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors have no commercial interest to disclose.


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Copyright information

© Society of Surgical Oncology 2014

Authors and Affiliations

  • Jean-François Le Brun
    • 1
  • Loic Campion
    • 1
  • Dominique Berton-Rigaud
    • 1
  • Gérard Lorimier
    • 2
  • Frédéric Marchal
    • 3
  • Gwenael Ferron
    • 4
  • Anne Sophie Oger
    • 2
  • François Dravet
    • 1
  • Isabelle Jaffre
    • 1
  • Jean-Marc Classe
    • 1
  1. 1.Institut de cancérologie de l’OuestSaint-HerblainFrance
  2. 2.ICO Paul PapinAngersFrance
  3. 3.ICL Alexis VautrinVandoeuvre Les NancyFrance
  4. 4.Institut Claudius RegaudToulouseFrance

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