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Annals of Surgical Oncology

, Volume 21, Issue 9, pp 3063–3068 | Cite as

Effect of Body Composition on Outcomes after Hepatic Resection for Hepatocellular Carcinoma

  • Shinji Itoh
  • Ken Shirabe
  • Yoshihiro Matsumoto
  • Shohei Yoshiya
  • Jun Muto
  • Norifumi Harimoto
  • Yo-ichi Yamashita
  • Toru Ikegami
  • Tomoharu Yoshizumi
  • Akihiro Nishie
  • Yoshihiko Maehara
Hepatobiliary Tumors

Abstract

Purpose

To evaluate the effect of body composition on outcomes after hepatic resection for patients with hepatocellular carcinoma (HCC).

Methods

We performed 190 hepatic resections for HCC and divided the patients into 2 groups on the basis of visceral fat area (VFA), assessed by computed tomographic measurement at the level of the umbilicus, into high VFA (H-VFA) (n = 106) and low VFA (L-VFA) (n = 84) groups. We compared the surgical outcomes between the two groups.

Results

L-VFA was significantly correlated with a lower body mass index, sarcopenia, lower serum albumin, and liver cirrhosis. There was no difference in the incidence of postoperative complications and mortality between the 2 groups. Patients in the L-VFA group had a significantly poorer prognosis than those in the H-VFA group in terms of both overall (P = 0.043) and recurrence-free (P = 0.001) survival. The results of multivariate analysis showed that sarcopenia rather than L-VFA was an independent and prognostic indicator after hepatic resection with HCC.

Conclusions

Body composition is an important factor affecting cancer outcomes after hepatic resection for HCC in Japan.

Keywords

Body Mass Index Hepatic Resection Serum Albumin Level Skeletal Muscle Mass Microvascular Invasion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Society of Surgical Oncology 2014

Authors and Affiliations

  • Shinji Itoh
    • 1
  • Ken Shirabe
    • 1
  • Yoshihiro Matsumoto
    • 1
  • Shohei Yoshiya
    • 1
  • Jun Muto
    • 1
  • Norifumi Harimoto
    • 1
  • Yo-ichi Yamashita
    • 1
  • Toru Ikegami
    • 1
  • Tomoharu Yoshizumi
    • 1
  • Akihiro Nishie
    • 2
  • Yoshihiko Maehara
    • 1
  1. 1.Department of Surgery and Science, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan
  2. 2.Department of Clinical Radiology, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan

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