Annals of Surgical Oncology

, Volume 21, Issue 7, pp 2188–2196 | Cite as

Breast-Conserving Therapy: A Viable Option for Young Women with Early Breast Cancer—Evidence from a Prospective Study

  • Zeming Xie
  • Xi Wang
  • Huanxin Lin
  • Weidong Wei
  • Peng Liu
  • Xiangsheng Xiao
  • Xiaoming Xie
  • Xunhang Guan
  • Mingtian Yang
  • Jun Tang
Breast Oncology
  • 366 Downloads

Abstract

Background

This study evaluated the security of breast-conserving treatment (BCT) in young patients and the effect of regional radiation therapy on young patients with 1–3 positive nodes (N+) treated with BCT.

Methods

In this prospective concurrent controlled study, 164 patients were defined as the BCT group, and regional radiation therapy was delivered to patients with 1–3 N+. Modified radical mastectomies (MRMs) were performed on 224 patients without regional radiation therapy.

Results

The 9-year local recurrence (LR) rate of the BCT was 7 %, compared with 3 % in the MRM group (p = 0.055). The 9-year regional recurrence (RR) rate was 6 % for the BCT group and 12 % for the MRM group (p = 0.048). The distant metastasis (DM)-free and breast cancer-specific survival rates were similar between the two groups. RR was an independent prognostic factor for DM [hazard ratio 3.27; 95 % confidence interval (CI) 1.726–6.208] and breast cancer-specific survival (hazard ratio 5.814; 95 % CI 2.690–12.568), whereas LR was not an independent prognostic factor for DM or breast cancer-specific survival.

Conclusions

Young patients treated with BCT have a higher LR rate than that of MRM. However, LR has no detrimental effect on DM-free and breast cancer-specific survival rates, whereas RR is a strong risk factor of DM and death. Regional radiation therapy for young patients with 1–3 N+ may reduce RR and improve survival rates.

Keywords

Local Recurrence Distant Metastasis Local Recurrence Rate Regional Recurrence Ipsilateral Breast Tumor Recurrence 

Notes

Acknowledgment

This work was supported by the Nature Science Foundation of China (project 81272895), the Natural Science Foundation of Guangdong in China (project S2012040006681), and the Foundation of the Ministry of Science and Technology of Guangdong Province (project 2011B080701052).

Conflict of interest

The authors declare no conflict of interest.

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Copyright information

© Society of Surgical Oncology 2014

Authors and Affiliations

  • Zeming Xie
    • 1
    • 2
  • Xi Wang
    • 1
    • 2
  • Huanxin Lin
    • 1
    • 3
  • Weidong Wei
    • 1
    • 2
  • Peng Liu
    • 1
    • 2
  • Xiangsheng Xiao
    • 1
    • 2
  • Xiaoming Xie
    • 1
    • 2
  • Xunhang Guan
    • 1
    • 3
  • Mingtian Yang
    • 1
    • 2
  • Jun Tang
    • 1
    • 2
  1. 1.State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouChina
  2. 2.Departments of Breast OncologySun Yat-sen University Cancer CenterGuangzhouChina
  3. 3.Departments of Radiation OncologySun Yat-sen University Cancer CenterGuangzhouChina

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