Salvage Surgery for Residual Primary and Locally Recurrent Anal Squamous Cell Carcinoma After Chemoradiotherapy in HIV-positive Individuals
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The treatment of anal cancer in human immunodeficiency virus (HIV) patients—as in the general population—is primarily with chemoradiotherapy (CRT), and abdominoperineal resection of residual or recurrent primary disease. The aim of this study was to evaluate the extent of residual primary disease and local recurrence as well as the outcome of salvage surgery after CRT for anal carcinoma in HIV-positive individuals.
We retrospectively studied HIV-positive anal carcinoma patients treated between February 1989 and November 2012 in a specialist London unit. Extent of residual primary disease, local recurrence after CRT, postoperative complications, and survival after salvage surgery were evaluated.
Complete response was experienced in 44 of 53 (83 %) of HIV patients treated with CRT for anal carcinoma. One patient (2.3 %) developed local recurrence. Nine patients (eight residual primary disease after CRT and one local recurrence) underwent salvage surgery after CRT. There were no perioperative deaths, and perioperative CD4 counts were sustained. Complications occurred in five patients (55 %). Median interval to complete perineal healing was 4 months (range 2–11 months), and median hospital stay was 29 days. Survival (median 16 months) was 25 % at 2 years from salvage surgery.
Results in HIV-positive patients receiving highly active antiretroviral therapy (HAART) suggest that loss of HIV sensitivity to HAART can be avoided, but that there is increased postoperative morbidity that may be related to HIV disease. Survival was comparable to that for salvage therapy after optimal CRT in non-HIV anal carcinoma patients.
KeywordsHuman Immunodeficiency Virus Anal Cancer Human Immunodeficiency Virus Disease Anal Carcinoma Anal Squamous Cell Carcinoma
The authors declare no conflict of interest.
- 5.UKCCCR Anal Cancer Trial Working Party; UK Co-ordinating Committee on Cancer Research. Epidermoid anal cancer: results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil, and mitomycin. Lancet. 1996;348(9034):1049–54.Google Scholar
- 9.Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A. Anal canal. AJCC cancer staging manual. 7th edn. New York: Springer; 2010. p. 119–26.Google Scholar
- 14.Harrison KM, Song R, Zhang X. Life expectancy after HIV diagnosis based on national HIV surveillance data from 25 states, United States. J AIDS. 2010;53:124–30.Google Scholar
- 18.Williams I, Churchill D, Anderson J, Boffito M, Bower M, Cairns G, et al. British HIV Association guidelines for the treatment of HIV-1-positive adults with antiretroviral therapy. HIV Med. 2012;13(Suppl 2):1–85.Google Scholar
- 20.Ferenschild FTJ, Vermaas M, Hofer SO, Verhoef C, Eggermont AM, de Wilt JHW. Salvage abdominoperineal resection and perineal wound healing in local recurrent or persistent anal cancer. World J Surg. 2005; 29(11):1452–7.Google Scholar
- 26.Sunesen KG, Buntzen S, Tei T, Lindegaard JC, Norgaard M, Laurberg S. Perineal healing and survival after anal cancer salvage surgery: 10-year experience with primary perineal reconstruction using the vertical rectus abdominis myocutaneous (VRAM) flap. Ann Surg Oncol. 2009;16:68–77.PubMedCrossRefGoogle Scholar
- 27.National Comprehensive Cancer Network Guidelines in Oncology. Anal carcinoma, version 1.2012. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed 15 Dec 2012.
- 29.Goh V, Gollub FK, Liaw J, Wellsted D, Przybytniak I, Padhani AR, et al. Magnetic resonance imaging assessment of squamous cell carcinoma of the anal canal before and after chemoradiation: can MRI predict for eventual clinical outcome? Int J Radiat Oncol Biol Phys. 2010;78:715–21.PubMedCrossRefGoogle Scholar