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Annals of Surgical Oncology

, Volume 20, Issue 13, pp 4090–4095 | Cite as

Prognosis of Solitary Fibrous Tumors: A Multicenter Study

  • Winan J. van Houdt
  • Charlotte M. A. Westerveld
  • Joyce E. P. Vrijenhoek
  • Joost van Gorp
  • Frits van Coevorden
  • Cornelis Verhoef
  • Thijs van Dalen
Bone and Soft Tissue Sarcomas

Abstract

Background

Solitary fibrous tumors (SFTs) are rare mesenchymal tumors, and data regarding outcome and prognostic factors are scarce. We report the outcome and analysis of prognostic factors of a retrospective multicenter cohort study for patients treated for SFTs.

Methods

Retrospective analysis was performed of patients treated for SFTs between 1995 and 2012. Clinical and histopathological features were analyzed for prognostic value. Endpoints were set at local recurrence, metastasis formation, or death. Survival was analyzed using Kaplan–Meier and Cox proportional hazards analyses.

Results

A total of 81 patients underwent surgical resection of a SFT with curative intent. During follow-up, 21 patients developed distant metastases, while 18 patients developed local recurrence. The 5-year overall survival was 84 %. The local recurrence rate and the metastasis rate at 5 years were 29 and 34 %, respectively. Of all factors analyzed, positive resection margin significantly correlated with local recurrence [hazard ratio (HR) 4.8; 95 % confidence interval (95 % CI) 1.5–14.9]. Tumor size >10 cm (HR 4.4; 95 % CI 1.7–11.5) and high mitosis rate (HR 3.3; 95 % CI 1.06–10.3) significantly correlated with higher incidence of metastases. The combination of tumors >10 cm and high mitosis rate significantly correlated with higher incidence of metastases (HR 4.8; 95 % CI 1.4–16.2) and showed a trend toward worse overall survival (HR 5.7; 95 % CI 0.95–34.7).

Conclusions

A substantial portion of patients with a SFT developed local recurrence or metastases. Local recurrence is significantly higher in patients with positive resection margins; metastasis frequency is significantly higher in patients with tumors >10 cm and tumors with a high mitosis rate.

Keywords

Local Recurrence Smooth Muscle Actin Epithelial Membrane Antigen Solitary Fibrous Tumor Metastasis Formation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Disclosures

None.

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Copyright information

© Society of Surgical Oncology 2013

Authors and Affiliations

  • Winan J. van Houdt
    • 1
    • 2
  • Charlotte M. A. Westerveld
    • 1
  • Joyce E. P. Vrijenhoek
    • 2
  • Joost van Gorp
    • 3
  • Frits van Coevorden
    • 4
  • Cornelis Verhoef
    • 5
  • Thijs van Dalen
    • 1
  1. 1.Department of SurgeryDiakonessenhuis Hospital UtrechtUtrechtThe Netherlands
  2. 2.Department of SurgeryUniversity Medical Center Utrecht (UMC)UtrechtThe Netherlands
  3. 3.Department of PathologyDiakonessenhuis Hospital UtrechtUtrechtThe Netherlands
  4. 4.Department of Surgical OncologyThe Netherlands Cancer InstituteAmsterdamThe Netherlands
  5. 5.Department of SurgeryErasmusMC-Daniel den Hoed Cancer CenterRotterdamThe Netherlands

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