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Annals of Surgical Oncology

, Volume 21, Issue 1, pp 93–99 | Cite as

Local Recurrence Patterns in Breast Cancer Patients Treated with Oncoplastic Reduction Mammaplasty and Radiotherapy

  • Bree R. Eaton
  • Albert Losken
  • Derick Okwan-Duodu
  • David M. Schuster
  • Jeffrey M. Switchenko
  • Donna Mister
  • Karen Godette
  • Mylin A. Torres
Breast Oncology

Abstract

Background

The purpose of this study was to describe the incidence and location of ipsilateral breast tumor recurrence (IBTR) among breast cancer patients treated with oncoplastic reduction mammoplasty (ORM) and radiotherapy (RT).

Methods

The medical records of 86 consecutive women with ductal carcinoma in situ (DCIS) (n = 11) or invasive carcinoma of the breast (n = 75) treated with ORM at Emory University between January 1994 and December 2010 were reviewed.

Results

Following ORM, prolonged wound healing or surgical complications led to delay of adjuvant chemotherapy or RT in 11 patients. Surgical clips were found outside the primary tumor breast quadrant in 43 % of the patients with available RT planning CT images. When the clips were found outside the primary tumor quadrant, the RT boost was more frequently delivered outside versus inside the primary tumor quadrant (67 vs. 33 %, p < 0.001). After a median follow-up period of 4.5 years (range 0.1–17.9), 6 patients developed an IBTR and only 1 IBTR occurred outside the primary tumor quadrant. The 5-year ipsilateral breast tumor control rates were 91 % (95 % CI 0.82–0.99) and 93 % (95 % CI 0.90–0.97) for patients with DCIS and invasive carcinoma, respectively.

Conclusions

The use of ORM yields acceptable rates of IBTR. ORM may displace breast tissue and surgical clips to breast quadrants outside of the original tumor location, but the majority of IBTRs still occur in the original tumor quadrant. This area remains at highest risk of in-breast recurrence in women treated with ORM irrespective of surgical clip location.

Keywords

Intensity Modulate Radiation Therapy Ipsilateral Breast Tumor Recurrence Breast Cancer Specific Survival Lumpectomy Cavity Diagnostic Mammogram 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Society of Surgical Oncology 2013

Authors and Affiliations

  • Bree R. Eaton
    • 1
    • 6
  • Albert Losken
    • 2
    • 6
  • Derick Okwan-Duodu
    • 1
    • 6
  • David M. Schuster
    • 3
    • 6
  • Jeffrey M. Switchenko
    • 4
    • 5
    • 6
  • Donna Mister
    • 1
    • 5
  • Karen Godette
    • 1
    • 6
  • Mylin A. Torres
    • 1
    • 6
  1. 1.Department of Radiation OncologyEmory UniversityAtlantaUSA
  2. 2.Division of Plastic Surgery, Department of SurgeryEmory UniversityAtlantaUSA
  3. 3.Division of Nuclear Medicine and Molecular Imaging, Department of Radiology and Imaging SciencesEmory UniversityAtlantaUSA
  4. 4.Department of Biostatistics & BioinformaticsEmory UniversityAtlantaUSA
  5. 5.Rollins School of Public HealthEmory UniversityAtlantaUSA
  6. 6.Winship Cancer InstituteEmory UniversityAtlantaUSA

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