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Annals of Surgical Oncology

, Volume 20, Issue 4, pp 1230–1239 | Cite as

Novel Multimodality Treatment Sequencing for Extrahepatic (Mid and Distal) Cholangiocarcinoma

  • Kiran K. Turaga
  • Susan Tsai
  • Lauren A. Wiebe
  • Douglas B. Evans
  • T. Clark Gamblin
Gastrointestinal Oncology

Abstract

Neoadjuvant chemoradiation has demonstrated significant advantages in the management of pancreatic adenocarcinoma. A similar tumor in a nearby anatomical location is extrahepatic cholangiocarcinoma, which has proven to be largely unresponsive to current forms of therapy. Neoadjuvant therapy for hilar cholangiocarcinoma has been combined with surgical resection and/or liver transplantation with a 25–33 % complete pathological response rate. We propose a wider application of neoadjuvant chemoradiation for patients with distal cholangiocarcinoma and present our rationale for this form of treatment sequencing.

Keywords

Gemcitabine Cholangiocarcinoma Complete Pathological Response Biliary Tract Cancer Hilar Cholangiocarcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Society of Surgical Oncology 2012

Authors and Affiliations

  • Kiran K. Turaga
    • 1
  • Susan Tsai
    • 1
  • Lauren A. Wiebe
    • 2
  • Douglas B. Evans
    • 1
  • T. Clark Gamblin
    • 1
  1. 1.Department of Surgery, Dvision of Surgical OncologyMedical College of WisconsinMilwaukeeUSA
  2. 2.Department of Medicine, Division of Hematology OncologyMedical College of WisconsinMilwaukeeUSA

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