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Novel Multimodality Treatment Sequencing for Extrahepatic (Mid and Distal) Cholangiocarcinoma

  • Gastrointestinal Oncology
  • Published:
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Abstract

Neoadjuvant chemoradiation has demonstrated significant advantages in the management of pancreatic adenocarcinoma. A similar tumor in a nearby anatomical location is extrahepatic cholangiocarcinoma, which has proven to be largely unresponsive to current forms of therapy. Neoadjuvant therapy for hilar cholangiocarcinoma has been combined with surgical resection and/or liver transplantation with a 25–33 % complete pathological response rate. We propose a wider application of neoadjuvant chemoradiation for patients with distal cholangiocarcinoma and present our rationale for this form of treatment sequencing.

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Authors and Affiliations

  1. Department of Surgery, Dvision of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI, USA

    Kiran K. Turaga MD, MPH, Susan Tsai MD, MHS, Douglas B. Evans MD & T. Clark Gamblin MD, MS

  2. Department of Medicine, Division of Hematology Oncology, Medical College of Wisconsin, Milwaukee, WI, USA

    Lauren A. Wiebe MD

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  1. Kiran K. Turaga MD, MPH
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  2. Susan Tsai MD, MHS
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  3. Lauren A. Wiebe MD
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Correspondence to Kiran K. Turaga MD, MPH.

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Turaga, K.K., Tsai, S., Wiebe, L.A. et al. Novel Multimodality Treatment Sequencing for Extrahepatic (Mid and Distal) Cholangiocarcinoma. Ann Surg Oncol 20, 1230–1239 (2013). https://doi.org/10.1245/s10434-012-2648-0

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