Annals of Surgical Oncology

, Volume 19, Issue 10, pp 3192–3198 | Cite as

Long-Term Results of Excision Followed by Radiofrequency Ablation as the Sole Means of Local Therapy for Breast Cancer

  • Misti Wilson
  • Soheila Korourian
  • Cristiano Boneti
  • Laura Adkins
  • Brian Badgwell
  • Jeannette Lee
  • V. Suzanne Klimberg
Breast Oncology

Abstract

Introduction

Clinical trials have yet to find a size or grade of invasive cancer which can be treated with lumpectomy alone due to the higher local recurrence (LR) rate without radiation (XRT). Excision followed by radiofrequency ablation (eRFA) is an intraoperative method which utilizes heat to create an additional tumor-free zone around the lumpectomy cavity. We hypothesized that eRFA after lumpectomy for invasive breast cancer could reduce the need for re-excision in close margins and potentially maintain local control without the need for XRT.

Methods

This institutional review board-approved study from July 2002 to December 2010 involved patients undergoing eRFA. A standard lumpectomy was performed and then the RFA probe was deployed 1 cm circumferentially into the walls of the lumpectomy cavity and maintained at 100 °C for 15 min. Validated doppler sonography was used to determine final ablation size.

Results

Seventy-three patients (mean age of 68.8 ± 10.9 years) with invasive cancer who had an average tumor size of 1.0 ± 0.54 cm (range of 0.2-2.6 cm) underwent eRFA. Margins were negative in 54, close in 10, focally positive in 6, and grossly positive in 3 patients. Sixteen out of 19 (84 %) of patients with close or positive margins were spared of re-excision. Median follow-up was 55 ± 21 months. Only one patient (1.3 %) developed an in site recurrence. There were three recurrences, elsewhere.

Conclusions

Long-term follow-up suggests that eRFA may reduce the need for re- excision as well as reduce LR for invasive breast cancer treated without XRT.

Keywords

Sentinel Lymph Node Biopsy Invasive Ductal Carcinoma Positive Margin Ipsilateral Breast Tumor Recurrence Completion Axillary Lymph Node Dissection 

Notes

Acknowledgments

This work was funded by grants from the QVC/FFANY, AngioDynamics, Inc. and the State of Arkansas Oversight Committee on Breast Cancer Research.

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Copyright information

© Society of Surgical Oncology 2012

Authors and Affiliations

  • Misti Wilson
    • 1
  • Soheila Korourian
    • 2
  • Cristiano Boneti
    • 1
  • Laura Adkins
    • 1
  • Brian Badgwell
    • 1
  • Jeannette Lee
    • 3
  • V. Suzanne Klimberg
    • 1
    • 2
  1. 1.Department of SurgeryUniversity of Arkansas for Medical SciencesLittle RockUSA
  2. 2.Department of PathologyUniversity of Arkansas for Medical SciencesLittle RockUSA
  3. 3.Department of BiostatisticsUniversity of Arkansas for Medical SciencesLittle RockUSA

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