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Keratin 17 Expression Correlates with Tumor Progression and Poor Prognosis in Gastric Adenocarcinoma

  • Gastrointestinal Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Keratin 17 (K17) is regarded as a basal/myoepithelial cell keratin and is known to be inducible in activated keratinocytes. The high frequency of K17 expression in pancreaticobiliary nonmucinous adenocarcinoma or basal-like breast carcinoma has previously been described. However, its expression in gastric cancer (GC) is controversial.

Methods

We investigated the clinicopathological features and prognostic significance of 192 patients with GC by immunohistochemical staining of tissue microarrays. Analysis of epithelial markers including K17, K14, and K5/6, cell cycle-associated proteins p53, Ki-67, and 14-3-3 sigma, and mucinous phenotype markers including CD10, CDX2, MUC5AC, and MUC6 was performed.

Results

Cytoplasmic expression of K17 was observed in 95 (49.5 %) of 192 patients with GC. K17 expression positively correlated with lymph node metastasis (P = 0.003) and advanced stages of the disease (P = 0.014). K17 expression was significantly correlated with 14-3-3 sigma expression (P < 0.001) and CD10 expression (P = 0.015). The overall survival rates of patients with K17-positive GC were significantly lower than those with negative K17 expression (50.5 vs. 71.1 %, P = 0.004). Univariate analysis revealed that K17 expression confers a poor prognosis in patients with GC (P = 0.004), and it was also an independent prognostic factor in multivariate analysis (P = 0.049).

Conclusions

K17 expression is correlated with tumor progression in GC and may serve as a biomarker for poor prognosis.

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Acknowledgment

We thank Aiko Nobusawa for the manufacture of silicon mold tissue array blocks, Makiko Saito for the construction of tissue arrays, and Toshiaki Hikino for immunohistochemistry.

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Authors and Affiliations

  1. Department of Diagnostic Pathology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan

    Munenori Ide MD, PhD, Toshihide Kato MD & Tetsunari Oyama MD, PhD

  2. Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan

    Munenori Ide MD, PhD, Toshihide Kato MD, Kyoichi Ogata MD, PhD, Erito Mochiki MD, PhD & Hiroyuki Kuwano MD, PhD

  3. Center for Medical Education, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan

    Munenori Ide MD, PhD

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  1. Munenori Ide MD, PhD
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  2. Toshihide Kato MD
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Correspondence to Munenori Ide MD, PhD.

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Ide, M., Kato, T., Ogata, K. et al. Keratin 17 Expression Correlates with Tumor Progression and Poor Prognosis in Gastric Adenocarcinoma. Ann Surg Oncol 19, 3506–3514 (2012). https://doi.org/10.1245/s10434-012-2437-9

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  • DOI: https://doi.org/10.1245/s10434-012-2437-9

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