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Annals of Surgical Oncology

, Volume 19, Issue 9, pp 2908–2916 | Cite as

Impact of Obesity and Body Fat Distribution on Survival After Pancreaticoduodenectomy for Pancreatic Adenocarcinoma

  • Sébastien Gaujoux
  • Javiera Torres
  • Sara Olson
  • Corrine Winston
  • Mithat Gonen
  • Murray F. Brennan
  • David S. Klimstra
  • Michael D’Angelica
  • Ronald DeMatteo
  • Yuman Fong
  • Michael House
  • William Jarnagin
  • Robert C. Kurtz
  • Peter J. Allen
Hepatobiliary Tumors

ABSTRACT

Background

Epidemiologic studies have reported a positive correlation between body mass index (BMI) and pancreatic cancer risk, but clinical relevance of obesity and/or body fat distribution on tumor characteristics and cancer-related outcome remain controversial. We sought to assess the influence of obesity and body fat distribution on pathologic characteristics and survival after pancreaticoduodenectomy for pancreatic adenocarcinoma.

Methods

Demographic and biometric data were collected on 328 patients undergoing pancreaticoduodenectomy for pancreatic ductal adenocarcinoma. In a subset of patients, pancreatic fatty infiltration and fibrosis were assessed pathologically, and visceral fat area (VFA) was evaluated. Influence of BMI and body fat distribution on tumor characteristics and survival were evaluated.

Results

A significant positive correlation between BMI and VFA was observed, with a wide range of VFA value within each BMI class. According to BMI or VFA distribution, there were no significant differences in patient characteristics, intraoperative or perioperative outcome, or pathologic characteristics, with the exception of significantly higher blood loss in patients with an increased body weight or VFA. Unadjusted overall and disease-free survival between BMI class and VFA quartile were not significantly different.

Conclusions

In this study, obesity and body fat distribution were not correlated with specific tumor characteristics or cancer-related outcome.

Keywords

Body Mass Index Pancreatic Cancer Pancreatic Adenocarcinoma Pancreatic Ductal Adenocarcinoma Pancreatic Cancer Risk 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

ACKNOWLEDGMENT

Sébastien Gaujoux was recipient of a grant from the European Society of Surgical Oncology (ESSO), the Association Française de Chirurgie Hépato-Biliaire et de Transplantation Hépatique (ACHBT).

CONFLICT OF INTEREST

None of the authors has any conflict of interest

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Copyright information

© Society of Surgical Oncology 2012

Authors and Affiliations

  • Sébastien Gaujoux
    • 1
  • Javiera Torres
    • 2
  • Sara Olson
    • 3
  • Corrine Winston
    • 4
  • Mithat Gonen
    • 3
  • Murray F. Brennan
    • 1
  • David S. Klimstra
    • 2
  • Michael D’Angelica
    • 1
  • Ronald DeMatteo
    • 1
  • Yuman Fong
    • 1
  • Michael House
    • 1
  • William Jarnagin
    • 1
  • Robert C. Kurtz
    • 5
  • Peter J. Allen
    • 1
  1. 1.Department of SurgeryMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  2. 2.Department of PathologyMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  3. 3.Department of Biostatistics and EpidemiologyMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  4. 4.Department of RadiologyMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  5. 5.Department of Gastroenterology and NutritionMemorial Sloan-Kettering Cancer CenterNew YorkUSA

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