Annals of Surgical Oncology

, Volume 19, Issue 6, pp 1766–1773 | Cite as

The Role of Tumor Markers in the Surgical Approach of Ovarian Masses in Pediatric Age: A 10-Year Study and a Literature Review

  • Claudio Spinelli
  • Valentina Pucci
  • Irene Buti
  • Josephine Liserre
  • Antonio Messineo
  • Francesco Bianco
  • Clara Ugolini
Healthcare Policy and Outcomes



The purpose of this study was to detect the role of serum tumor markers in the differential diagnosis and in the choice of the surgical treatment of ovarian lesions in pediatric age.


We retrospectively reviewed medical charts of all pediatric girls operated in two pediatric centers during a 10-year period. The following features were analyzed: age at the moment of presentation, symptoms, diagnostic studies, surgical approach, pathological findings, and, in particular, serum tumor markers. Also, a literature review and statistical analysis (χ2 test) concerning the increase of different tumor markers in benign and malignant ovarian lesions were related to the study.


A total of 120 children with 127 ovarian masses (7 with bilateral pathologies) were reviewed. Pathology showed 61 nonneoplastic lesions (48%), 54 benign tumors (42.5%), 5 malignant tumors (4%), and 7 torsed normal ovaries (5.5%). The evaluation of serum tumor markers was performed in 106 cases and was positive in 16 (15.1%): in all of the 5 cases (100%) of malignant neoplastic lesions and in 11 (20.4%) benign neoplastic ones. The literature review confirmed these data, and statistical analysis highlighted them as significant values.


The role of tumor markers is still controversial. This is the reason why, before considering a radical treatment, we suggest caution to optimize future fertility.


Tumor Marker Inhibin Precocious Puberty Serum Tumor Marker Ovarian Mass 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors have nothing to disclose.


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Copyright information

© Society of Surgical Oncology 2012

Authors and Affiliations

  • Claudio Spinelli
    • 1
  • Valentina Pucci
    • 1
  • Irene Buti
    • 1
  • Josephine Liserre
    • 1
  • Antonio Messineo
    • 2
  • Francesco Bianco
    • 3
  • Clara Ugolini
    • 4
  1. 1. Department of SurgeryUniversity of PisaPisaItaly
  2. 2.Department of Pediatric Surgery, Children’s Hospital A. MeyerUniversity of FlorenceFlorenceItaly
  3. 3.Faculty of Mathematical, Physical and Natural SciencesUniversity of PisaPisaItaly
  4. 4.Department of Laboratory Medicine and Integrated Diagnostics, Section of Experimental PathologyUniversity of PisaPisaItaly

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