Duodenal Adenocarcinoma: Clinicopathologic Analysis and Implications for Treatment
- 636 Downloads
Duodenal adenocarcinoma is a rare cancer usually studied as a group with periampullary or small bowel adenocarcinoma; therefore, its natural history is poorly understood.
Patients with duodenal adenocarcinoma were identified from a single-institution pancreaticoduodenectomy database. Patients with adenocarcinoma arising from the ampulla of Vater were excluded. Univariate and multivariate analyses were performed to identify clinicopathologic variables associated with survival and recurrence after resection.
From 1984 to 2006, a total of 122 patients with duodenal adenocarcinoma underwent pancreaticoduodenectomy. Overall survival after resection was 48% at 5 years and 41% at 10 years. Five-year survival decreased as the number of lymph nodes involved by metastasis increased from 0 to 1–3 to ≥4 (68%, 58%, 17%, respectively, P < 0.01) and as the lymph node ratio increased from 0 to >0–0.2 to >0.2–0.4 to >0.4 (68%, 57%, 14%, 14%, respectively, P < 0.01). Lymph node metastasis was the only independent predictor of decreased survival in multivariate analysis. Recurrence after resection was predominantly distant (81%). Adjuvant chemoradiation did not decrease local recurrence or prolong overall survival; however, patients who received chemoradiation more commonly had nodal metastasis (P = 0.03).
The prognostic significance of both the absolute number and ratio of involved lymph nodes emphasizes the need for adequate lymphadenectomy to accurately stage duodenal adenocarcinoma. The mostly distant pattern of recurrence underscores the need for the development of effective systemic therapies.
KeywordsPerineural Invasion Adjuvant Chemoradiotherapy Adjuvant Chemoradiation Synchronous Liver Metastasis Small Bowel Adenocarcinoma
- 14.Rotman N, Pezet D, Fagniez PL, et al. Adenocarcinoma of the duodenum: factors influencing survival. French Association for Surgical Research. Br J Surg. 1994;81:83–5.Google Scholar
- 20.Sexe RB, Wade TP, Virgo KS, et al. Incidence and treatment of periampullary duodenal cancer in the U.S. veteran patient population. Cancer. 1996;77:251–4.Google Scholar
- 24.R: a language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing Development Core Team, 2007.Google Scholar
- 25.Edge SB, Byrd DR, Compton CC, et al. American Joint Committee on Cancer (AJCC) staging manual. 7th ed. New York: Springer-Verlag, 2010.Google Scholar
- 30.Yeo CJ, Cameron JL, Lillemoe KD, et al. Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma, part 2: randomized controlled trial evaluating survival, morbidity, and mortality. Ann Surg. 2002;236:355–66.PubMedCrossRefGoogle Scholar