Different Expression Patterns of CEACAM1 and its Impacts on Angiogenesis in Gastric Nonneoplastic and Neoplastic Lesions
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This study was designed to investigate the expression patterns of CEACAM1 and its relationship with angiogenesis in nonneoplastic and neoplastic gastric lesions.
CEACAM1 and TGF-β expression was detected by immunohistochemical staining and dual-labeling immunohistochemical staining in neoplastic and nonneoplastic lesions. MVD-CD31 and MVD-CD105 were counted in CEACAM1-positive areas by dual-labeling immunohistochemistry.
There was no expression of CEACAM1 in normal gastric mucosa. In IM and GIN, CEACAM1 was mainly expressed with membranous pattern. CEACAM1 was expressed with membranous pattern in well-differentiated adenocarcinoma, with cytoplasmic pattern in poorly differentiated adenocarcinoma, and with cytoplasmic and membranous pattern mixed together in intermediately adenocarcinoma. The expression patterns of CEACAM1 showed a significant difference (P < 0.05) in nonneoplastic and neoplastic lesions. Coexpression of CEACAM1 and TGF-β was elevated and significantly different from nonneoplastic to neoplastic lesions (P < 0.05). Moreover, CEACAM1 and TGF-β coexpression were related to carcinoma progression (r = 0.35; P < 0.05). MVD-CD31 and MVD-CD105 showed significant differences from nonneoplastic to neoplastic lesions (P < 0.05).
CEACAM1 has different expression patterns in nonneoplastic and neoplastic lesions. The coexpression of CEACAM1 and TGF-β increased from nonneoplastic to neoplastic lesions and may be related with tumor progression via promoting tumorous angiogenesis.
KeywordsCD105 Intestinal Metaplasia Normal Mucosa Neoplastic Lesion Prostate Intraepithelial Neoplasia
- 14.Riethdorf L, Lisboa BW, Henkel U, Naumann M, Wagener C, Löning T. Differential expression of CD66a (BGP), a Cell adhesion molecule of the carcinoembryonic antigen family, in benign, premalignant, and malignant lesions of the human mammary gland. J Histochem Cytochem. 1997;45:957–64.PubMedCrossRefGoogle Scholar
- 27.Hamilton SR, Aaltonen LA. WHO classification of tumours: Pathology and genetics of tumours of the digestive system. IARC Press: Lyon; 2000.Google Scholar
- 28.Kleinerman DI, Troncoso P, Lin SH, Pisters LL, Sherwood ER, Brooks T, et al. Consistent expression of an epithelial cell adhesion molecule (c-cam) during human prostate development and loss of expression in prostate cancer: implication as a tumor suppressor. Cancer Res. 1995;55:1215–20.PubMedGoogle Scholar
- 30.Riethdorf L, Lisboa BW, Henkel U, Naumann M, Wagener C, Löning T. Differential expression of CEACAM1 (bgp), a cell adhesion molecule of the carcinoembryonic antigen family, in benign, premalignant and malignant lesions of the human mammary gland. J Histochem Cytochem. 1997;45:957–63.PubMedCrossRefGoogle Scholar
- 31.Yamato Y, Koike T, Yoshiya K, Fukui M, Kitahara A, Toyabe S. Factors influencing long-term survival and surgical indications for pulmonary metastasectomy for metastases from colorectal cancer. Thoracic Cancer. 2011. doi: 10.1111/j.1759-7714.2011.00044.x.