Annals of Surgical Oncology

, Volume 19, Supplement 3, pp 365–374 | Cite as

Different Expression Patterns of CEACAM1 and its Impacts on Angiogenesis in Gastric Nonneoplastic and Neoplastic Lesions

  • Jian-Qiang Guo
  • Wei-Hua Yu
  • Hong-Juan Wang
  • Bin Liu
  • Kong-Xi Zhu
  • Qing-Hui Zhang
  • Ting-Guo Zhang
  • Wei-Hua Xu
  • Hong-Bo Wang
  • Hong-Li Wu
  • Cheng-Jun Zhou
Translational Research and Biomarkers



This study was designed to investigate the expression patterns of CEACAM1 and its relationship with angiogenesis in nonneoplastic and neoplastic gastric lesions.


CEACAM1 and TGF-β expression was detected by immunohistochemical staining and dual-labeling immunohistochemical staining in neoplastic and nonneoplastic lesions. MVD-CD31 and MVD-CD105 were counted in CEACAM1-positive areas by dual-labeling immunohistochemistry.


There was no expression of CEACAM1 in normal gastric mucosa. In IM and GIN, CEACAM1 was mainly expressed with membranous pattern. CEACAM1 was expressed with membranous pattern in well-differentiated adenocarcinoma, with cytoplasmic pattern in poorly differentiated adenocarcinoma, and with cytoplasmic and membranous pattern mixed together in intermediately adenocarcinoma. The expression patterns of CEACAM1 showed a significant difference (P < 0.05) in nonneoplastic and neoplastic lesions. Coexpression of CEACAM1 and TGF-β was elevated and significantly different from nonneoplastic to neoplastic lesions (P < 0.05). Moreover, CEACAM1 and TGF-β coexpression were related to carcinoma progression (r = 0.35; P < 0.05). MVD-CD31 and MVD-CD105 showed significant differences from nonneoplastic to neoplastic lesions (P < 0.05).


CEACAM1 has different expression patterns in nonneoplastic and neoplastic lesions. The coexpression of CEACAM1 and TGF-β increased from nonneoplastic to neoplastic lesions and may be related with tumor progression via promoting tumorous angiogenesis.


CD105 Intestinal Metaplasia Normal Mucosa Neoplastic Lesion Prostate Intraepithelial Neoplasia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Society of Surgical Oncology 2011

Authors and Affiliations

  • Jian-Qiang Guo
    • 1
  • Wei-Hua Yu
    • 1
  • Hong-Juan Wang
    • 1
  • Bin Liu
    • 1
  • Kong-Xi Zhu
    • 1
  • Qing-Hui Zhang
    • 2
  • Ting-Guo Zhang
    • 2
  • Wei-Hua Xu
    • 1
  • Hong-Bo Wang
    • 1
  • Hong-Li Wu
    • 1
  • Cheng-Jun Zhou
    • 1
  1. 1.Department of Digestive Disease, The Second HospitalShandong UniversityJinanPeople’s Republic of China
  2. 2.Department of PathologyShandong University School of MedicineJinanPeople’s Republic of China

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