Annals of Surgical Oncology

, Volume 18, Issue 12, pp 3353–3361 | Cite as

Survival Factors in Patients with Recurrence After Curative Resection of Esophageal Squamous Cell Carcinomas

  • Hiroshi Miyata
  • Makoto Yamasaki
  • Yukinori Kurokawa
  • Shuji Takiguchi
  • Kiyokazu Nakajima
  • Yoshiyuki Fujiwara
  • Koji Konishi
  • Masaki Mori
  • Yuichiro Doki
Gastrointestinal Oncology



Approximately half of patients who undergo curative resection for esophageal cancers develop recurrence postoperatively. The factors affecting survival after such recurrence remain largely unknown.


To investigate factors affecting survival after recurrence in patients who had undergone curative resection for esophageal cancer, we retrospectively reviewed data for 461 patients who underwent curative esophagectomy with or without preoperative therapy for esophageal squamous cell carcinoma from January 1996 to December 2007. The correlations between several clinicopathological factors and survival after recurrence were examined.


Recurrence occurred in 196 of 461 patients (42.5%), with a median survival time after recurrence of 8.2 months. Multivariate analysis identified advanced tumor stage, preoperative chemoradiotherapy (CRT), number of recurrent tumors, and the presence of recurrence at the local site and liver as associated with shortened survival after recurrence. The analysis also indicated that treatment of the recurrence prolonged survival regardless of the treatment type. Although the pattern of recurrence did not significantly differ according to type of preoperative therapy, patients who underwent preoperative CRT were less often treated with radiotherapy for recurrence. Patients with multiple recurrent tumors less often received radiotherapy or surgery than those with a solitary recurrence. Chemotherapy for recurrence was not associated with either preoperative therapy or the number of recurrences.


Our retrospective study showed that multiple recurrent tumors and preoperative CRT limit the available treatment for recurrence and thereby are associated with poor prognosis. Vigorous treatment for recurrence can extend survival after recurrence in patients who undergo esophagectomy.


Esophageal Cancer Esophageal Squamous Cell Carcinoma Recurrent Disease Curative Resection Preoperative Chemotherapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Society of Surgical Oncology 2011

Authors and Affiliations

  • Hiroshi Miyata
    • 1
  • Makoto Yamasaki
    • 1
  • Yukinori Kurokawa
    • 1
  • Shuji Takiguchi
    • 1
  • Kiyokazu Nakajima
    • 1
  • Yoshiyuki Fujiwara
    • 1
  • Koji Konishi
    • 2
  • Masaki Mori
    • 1
  • Yuichiro Doki
    • 1
  1. 1.Department of Gastroenterological Surgery, Graduate School of MedicineOsaka UniversityOsakaJapan
  2. 2.Radiation Oncology, Graduate School of MedicineOsaka UniversityOsakaJapan

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