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The Negative Effect of Triple-Negative Breast Cancer on Outcome after Breast-Conserving Therapy

  • Breast Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate disease failure patterns and overall survival (OS) of women with triple-negative (TN) breast cancer who underwent breast-conserving therapy (BCT) and to understand the relationship of TN tumors with other prognostic factors.

Patients and Methods

The Surveillance, Epidemiology, and End Results (SEER) registry identified 562 women diagnosed and/or treated with unilateral invasive breast cancer during 2003–2004 at three Emory hospitals. After medical record review, 193 eligible women, with all tumor types, received BCT. Primary endpoints (local, regional, and distant recurrences) and secondary endpoint (OS) were evaluated using chi-square tests and Cox proportional hazards models.

Results

Of the 193 women, 33 (17.1%) had TN tumors and 160 (82.9%) had non-TN tumors. Patient characteristics were similar between the two tumor types; however, tumor grade and use of chemotherapy and hormones differed between the two groups. Median follow-up was 3.4 years; 22 patients had recurrence (12.2%), and 12 died (6.2%). Patients with TN tumors had higher local (12% versus 4% for non-TN) and distant recurrences (15% versus 4% for non-TN) rates (p = 0.01). On multivariate survival analyses, TN status [hazard ratio (HR) 1.8, 95% confidence interval (CI) 1.13–2.93] and African American (AA) race (HR 1.9, 95%CI 1.2–3.07) were independent predictors of inferior OS.

Conclusions

Patients with TN breast cancer showed significant increases in local and distant metastatic recurrence rates after BCT, and TN status and AA race were independent negative predictors of survival. For the future, identification of these high risk features may bring personalized medicine closer to reality.

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Acknowledgment

M.J.L. received funding from Sindab Endowment, Avon Breast Cancer Grant, and as a Glen Scholar.

Conflicts of interest

There are no disclaimers or conflicts of interest.

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Authors and Affiliations

  1. Department of Radiation Oncology, Emory University Winship Cancer Center, Atlanta, GA, USA

    Sandra S. Zaky MD, Karen D. Godette MD, Jonathan J. Beitler MD, Leslie R. Holmes MD, Esther S. Yu, David S. Yu MD, PhD & Jerome C. Landry MD, MBA

  2. Departments of Epidemiology and Hematology/Oncology (Joint), Rollins School of Public Health & Emory School of Medicine, Emory University Winship Cancer Center, Atlanta, GA, USA

    MaryJo Lund PhD

  3. Department of Hematology/Medical Oncology, Emory University Winship Cancer Center, Atlanta, GA, USA

    Kelly A. May MD & Ruth M. O’Regan MD

Authors
  1. Sandra S. Zaky MD
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  2. MaryJo Lund PhD
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  3. Kelly A. May MD
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  4. Karen D. Godette MD
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  5. Jonathan J. Beitler MD
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  6. Leslie R. Holmes MD
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  7. Ruth M. O’Regan MD
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  8. Esther S. Yu
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  9. David S. Yu MD, PhD
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  10. Jerome C. Landry MD, MBA
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Corresponding author

Correspondence to Jerome C. Landry MD, MBA.

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Zaky, S.S., Lund, M., May, K.A. et al. The Negative Effect of Triple-Negative Breast Cancer on Outcome after Breast-Conserving Therapy. Ann Surg Oncol 18, 2858–2865 (2011). https://doi.org/10.1245/s10434-011-1669-4

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  • DOI: https://doi.org/10.1245/s10434-011-1669-4

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