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A Prospective Comparison of the Prognostic Value of Tumor- and Patient-Related Factors in Patients Undergoing Potentially Curative Surgery for Pancreatic Ductal Adenocarcinoma

  • Pancreatic Tumors
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Outcome prediction after resection with curative intent for pancreatic ductal adenocarcinoma remains a challenge. There is increasing evidence that the presence of an ongoing systemic inflammatory response is associated with poor outcome in patients undergoing resection for a variety of common solid tumors. Our aim was to prospectively evaluate the prognostic value of tumor- and patient-related factors including the systemic inflammatory response in patients undergoing potentially curative surgery for pancreatic ductal adenocarcinoma of the head of pancreas.

Methods

The prognostic impact of tumor factors such as stage and host factors, including the systemic inflammatory response (modified Glasgow Prognostic Score [mGPS]), were evaluated in a prospective study of 135 patients who underwent elective pancreaticoduodenectomy for pancreatic ductal adenocarcinoma from January 2002 to April 2009.

Results

In addition to the established tumor-related pathological factors (in particular margin involvement; hazard ratio [HR] 2.82, 95% confidence interval [CI] 1.65–4.84, P < 0.001), an elevated mGPS (HR 2.26, 95% CI 1.43–3.57, P < 0.001) was independently associated with lower overall survival after pancreaticoduodenectomy. Additionally, in an adjuvant therapy subgroup of 74 patients, both margin involvement and an elevated mGPS remained independently associated with reduced overall survival.

Conclusions

We have prospectively validated the influence of tumor-related and patient-related factors. Margin involvement and the preoperative mGPS were the most important determinants of overall survival in patients undergoing potentially curative pancreaticoduodenectomy. Furthermore, both had independent prognostic value in those patients receiving adjuvant chemotherapy. In the future, this may be considered a stratification factor for entry onto therapeutic trials.

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Acknowledgment

N.B.J. undertook this work while supported by a Clinical PhD Fellowship from the Chief Scientist’s Office of the Scottish Government. The authors thank Dr. Ian Stewart for diagnostic imaging, Dr. Alex MacDonald for medical oncology management, pancreatic audit secretary Diane Stewart, and the West of Scotland Pancreatic Unit nurse specialists Elspeth Cowan, Alison Sinclair, and Linda Dewar for follow-up data.

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Authors and Affiliations

  1. Department of Surgery, Glasgow University, Glasgow, Scotland, UK

    Nigel B. Jamieson MRCS, Simon M. Denley MD, Jennifer Logue MRCS, Douglas J. MacKenzie MBChB & Donald C. McMillan PhD

  2. Department of Pathology, Glasgow University, Glasgow, Scotland, UK

    Alan K. Foulis MD

  3. West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Alexandra Parade, Glasgow, Scotland, UK

    Euan J. Dickson MD, Clem W. Imrie FRCS, Ross Carter MD & Colin J. McKay MD

Authors
  1. Nigel B. Jamieson MRCS
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  2. Simon M. Denley MD
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  3. Jennifer Logue MRCS
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  4. Douglas J. MacKenzie MBChB
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Correspondence to Nigel B. Jamieson MRCS.

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Jamieson, N.B., Denley, S.M., Logue, J. et al. A Prospective Comparison of the Prognostic Value of Tumor- and Patient-Related Factors in Patients Undergoing Potentially Curative Surgery for Pancreatic Ductal Adenocarcinoma. Ann Surg Oncol 18, 2318–2328 (2011). https://doi.org/10.1245/s10434-011-1560-3

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  • DOI: https://doi.org/10.1245/s10434-011-1560-3

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