Comparison of 6th and 7th AJCC TNM Staging Classification for Carcinoma of the Stomach in China
- 657 Downloads
The 7th edition of American Joint Committee on Cancer tumor-node-metastasis (AJCC TNM) staging system was put into use recently. The study aimed to evaluate its predictive ability on survival and compare the difference between the 6th and 7th editions of AJCC TNM system in gastric carcinoma.
Materials and Methods
A total of 1000 gastric carcinoma patients receiving treatment in our center were selected for the analysis. Patients were staged using both the 6th and 7th editions AJCC TNM staging system. Survival analysis was performed with a Cox regression model.
Of previous stage IV patients, 39.9% (112 of 281) migrated to a lower tier in the 7th edition. By setting the cutoff of positive lymph nodes as 0, 2, 6, and 15, the 7th edition strengthens the role of positive lymph nodes. Multivariable regression analysis showed that both 6th and 7th TNM stage systems were independent factors for overall survival. For lymph nodes negative patients, the 5-year overall survival for patients with fewer than 15 resected lymph nodes was significantly lower than those with more than 15.
AJCC 7th is not superior to AJCC 6th in predicting the 5-year overall survival rates of gastric adenocarcinoma patients. The definition of stage IV and the selection of cutoffs for MLNC in the AJCC 7th system is much more reasonable compared with the AJCC 6th system.
KeywordsResected Lymph Node Angiolymphatic Invasion Gastric Adenocarcinoma Patient Edition Staging System
This work was supported by National Natural Science Foundation of China grant 30672408, Guangzhou Bureau of Science and Technology grant 2006Z3-E0041, and Sun Yat-sen University 985 Program Initiation Fund (China). We gratefully thank the staff members in the Department of Medical Oncology and GI Surgery Oncology at Sun Yat-sen University Cancer Center for their suggestion and assistance.
- 3.Ichikura T, Tomimatsu S, Uefuji K, Kimura M, Uchida T, Morita D, et al. Evaluation of the New American Joint Committee on Cancer/International Union Against Cancer classification of lymph node metastasis from gastric carcinoma in comparison with the Japanese classification. Cancer. 1999;86:553–8.PubMedCrossRefGoogle Scholar
- 5.Greene FL, Page DL, Fleming ID, Fritz A, Balch CM, Haller DG, et al. American Joint Committee on Cancer (AJCC) cancer staging manual. 6th ed. New York, NY: Springer; 2002.Google Scholar
- 6.Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A. American Joint Committee on Cancer (AJCC) cancer staging manual. 7th ed. Chicago: Springer, 2010.Google Scholar
- 12.Hundahl SA, Phillips JL, Menck HR. The National Cancer Data Base Report on poor survival of U.S. gastric carcinoma patients treated with gastrectomy, 5th ed. American Joint Committee on Cancer staging, proximal disease, and the “different disease” hypothesis. Cancer. 2000;88:921–32.PubMedCrossRefGoogle Scholar