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Annals of Surgical Oncology

, Volume 18, Issue 1, pp 160–165 | Cite as

Simultaneous Indocyanine Green and 99mTc-Antimony Sulfur Colloid-Guided Laparoscopic Sentinel Basin Dissection for Gastric Cancer

  • Do Joong Park
  • Hyung-Ho Kim
  • Young Soo Park
  • Hye Seung Lee
  • Won Woo Lee
  • Hyuk-Joon Lee
  • Han-Kwang Yang
Gastrointestinal Oncology

Abstract

Background

There are few reports on a dual dye and isotope approach using laparoscopy in gastric cancer sentinel node mapping. The aim of this study is to evaluate the feasibility of laparoscopic sentinel basin dissection for gastric cancer using simultaneous indocyanine green (ICG) and 99mTc-antimony sulfur colloid (ASC) injections.

Methods

Sixty-eight patients were enrolled who had been diagnosed with cT1–T2 and cN0 stage gastric cancers. They underwent laparoscopic sentinel basin dissection between June 2005 and May 2008. ICG and 99mTc-tin colloid (separate injections in the first phase, n = 16) or ICG and 99mTc-ASC (simultaneous injections in the second phase, n = 52) were injected into the submucosa endoscopically. After performing the sentinel basin dissection, laparoscopy-assisted gastrectomy with curative lymphadenectomy was done. Green-stained or radioactive sentinel nodes (SNs) were analyzed by hematoxylin and eosin staining and by immunohistochemistry for cytokeratin.

Results

SNs were identified in 62 of the 68 patients (91.2%; mean 3.3 per patient). Eighteen patients had lymph node metastases. The sensitivity and specificity were, respectively, 72.2 and 100% using the dye method and 83.3 and 100% by the isotope method. However, the dual dye/isotope procedure improved both sensitivity and specificity to 100%. Patients receiving this protocol had significantly more SNs than those receiving separate ICG and 99mTc-tin colloid injections (3.3 vs. 1.9, P = 0.008).

Conclusion

Simultaneous ICG and 99mTc-ASC-guided laparoscopic sentinel basin dissection is an effective tool for gastric cancer SN mapping, giving a high detection rate and excellent sensitivity.

Keywords

Gastric Cancer Sentinel Node Sentinel Node Biopsy Early Gastric Cancer Sentinel Node Mapping 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgment

This study was supported by a grant of the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare, and Family Affairs, Republic of Korea (A085125).

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Copyright information

© Society of Surgical Oncology 2010

Authors and Affiliations

  • Do Joong Park
    • 1
  • Hyung-Ho Kim
    • 1
  • Young Soo Park
    • 2
  • Hye Seung Lee
    • 3
  • Won Woo Lee
    • 4
  • Hyuk-Joon Lee
    • 5
  • Han-Kwang Yang
    • 5
  1. 1.Department of Surgery, Seoul National University College of MedicineSeoul National University Bundang HospitalSeongnamKorea
  2. 2.Department of Internal MedicineSeoul National University Bundang HospitalSeongnamKorea
  3. 3.Department of PathologySeoul National University Bundang HospitalSeongnamKorea
  4. 4.Department of Nuclear MedicineSeoul National University Bundang HospitalSeongnamKorea
  5. 5.Department of SurgerySeoul National University HospitalSeoulKorea

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