Annals of Surgical Oncology

, Volume 17, Issue 10, pp 2545–2553 | Cite as

Utilization of Total Thyroidectomy for Differentiated Thyroid Cancer in Children

  • Mehul V. Raval
  • David J. Bentrem
  • Andrew K. Stewart
  • Clifford Y. Ko
  • Marleta Reynolds
Healthcare Policy and Outcomes



Recent recommendations suggest that total thyroidectomy (TT) is the surgical management of choice for differentiated thyroid cancer in children. The objective of this study is to assess trends in extent of surgical resection for differentiated thyroid cancer in children over the past two decades and to identify patient, tumor or hospital factors associated with use of TT.

Patients and Methods

Of 8,013 patients (aged 0–21 years) with differentiated thyroid cancer from the National Cancer Data Base (1985–2007), 5,933 (74%) underwent TT. Trends in extent of surgery were examined. Logistic regression was used to identify factors that predict use of TT.


Use of TT increased from 50.6% in 1985 to 84% in 2007 (P < 0.001). Patients were more likely to undergo TT if they had higher household income or had private insurance (P = 0.002 and P = 0.037). Patients were more likely to undergo TT if they had larger tumors or if there were nodal metastases present at time of resection (both P < 0.001). After adjusting for patient and tumor factors, patients treated at high-volume or Children’s Oncology Group hospitals were more likely to undergo TT than patients treated at low-volume or non-Children’s Oncology Group hospitals (P < 0.001).


Overall utilization of TT in children with differentiated thyroid cancer has steadily increased over the past 23 years in the USA. Variations in use of TT are not only related to tumor factors including size and nodal involvement, but also are also related to socioeconomic and hospital factors, demonstrating disparities in care.


Thyroid Cancer Total Thyroidectomy Papillary Thyroid Cancer Differentiate Thyroid Cancer National Cancer Data Base 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



M.V.R. participates in the American College of Surgeons Clinical Scholars in Residence Program. M.V.R. is supported by the John Gray Research Fellowship and the Daniel F. and Ada L. Rice Foundation. D.J.B. is supported by a career development award from the Department of Veterans Affairs, Veterans Health Administration, Health Services Research and Development Service. The National Cancer Data Base is supported by the American College of Surgeons, Commission on Cancer, and the American Cancer Society.


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Copyright information

© Society of Surgical Oncology 2010

Authors and Affiliations

  • Mehul V. Raval
    • 1
    • 2
    • 3
  • David J. Bentrem
    • 3
    • 4
  • Andrew K. Stewart
    • 1
  • Clifford Y. Ko
    • 1
    • 5
    • 6
  • Marleta Reynolds
    • 2
  1. 1.Division of Research and Optimal Patient Care, Cancer ProgramsAmerican College of SurgeonsChicagoUSA
  2. 2.Division of Pediatric SurgeryChildren’s Memorial HospitalChicagoUSA
  3. 3.Division of Gastrointestinal and Oncologic Surgery, Department of SurgeryNorthwestern University Feinberg School of MedicineChicagoUSA
  4. 4.Jesse Brown VA Medical CenterChicagoUSA
  5. 5.Department of SurgeryUniversity of California Los AngelesLos AngelesUSA
  6. 6.VA Greater Los Angeles Healthcare SystemLos AngelesUSA

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