Annals of Surgical Oncology

, Volume 17, Issue 10, pp 2779–2786 | Cite as

CEA-Antigen and SCC-Antigen mRNA Expression in Peripheral Blood Predict Hematogenous Recurrence After Resection in Patients with Esophageal Cancer

  • Koji Tanaka
  • Masahiko Yano
  • Masaaki Motoori
  • Kentaro Kishi
  • Isao Miyashiro
  • Tatsushi Shingai
  • Kunihito Gotoh
  • Shingo Noura
  • Hidenori Takahashi
  • Masayuki Ohue
  • Terumasa Yamada
  • Hiroaki Ohigashi
  • Takashi Yamamoto
  • Tomoyuki Yamasaki
  • Yuichiro Doki
  • Osamu Ishikawa
Thoracic Oncology

Abstract

Background

Although several studies have suggested an association between circulating tumor cells (CTC) and prognosis after esophageal cancer surgery, large-scale studies are lacking. The aim of this study was to prospectively examine the correlation between CTC and outcome in a large number of patients who underwent esophagectomy.

Materials and Methods

A cohort of 244 patients with squamous cell carcinoma of the esophagus who underwent curative surgery between 2002 and 2007 were prospectively analyzed for CTC before surgery and after the thoracic procedure. Reverse transcription-polymerase chain reaction for CEA and SCC antigen mRNA was used to detect cancer cells in the peripheral blood. CTC was defined as positive when at least 1 tumor marker mRNA was detected.

Results

CTC was positive in 34 patients (13.9%) before surgery and in 41 patients (16.8%) after the thoracic procedure. Multivariate analysis identified tumor depth (hazard ratio [HR], 0.439; 95% confidence interval [95% CI], 0.268–0.722; P = 0.0012), lymph node metastasis (HR, 2.467; 95% CI, 1.436–4.237; P = 0.0011), venous invasion (HR, 1.802; 95% CI, 1.082–3.002; P = 0.0236), and CTC status after the thoracic procedure (HR, 1.647; 95% CI, 1.032–2.629; P = 0.0365) as independent prognostic factors of disease-free survival. The rates of hematogenous (P = 0.0222) and local (P = 0.0464) recurrences were significantly higher in patients with CTC(+) after the thoracic procedure than those with CTC(−) after the thoracic procedure. Responders to neoadjuvant chemotherapy showed less lymphatic invasion and a decreased positive CTC rate after the thoracic procedure than nonresponders.

Conclusions

CTC status after the thoracic procedure is a useful predictor for hematogenous and local recurrences in patients with esophageal cancer.

Keywords

Esophageal Cancer Circulate Tumor Cell Lymphatic Invasion Venous Invasion Esophageal Cancer Cell Line 

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Copyright information

© Society of Surgical Oncology 2010

Authors and Affiliations

  • Koji Tanaka
    • 1
  • Masahiko Yano
    • 1
  • Masaaki Motoori
    • 1
  • Kentaro Kishi
    • 1
  • Isao Miyashiro
    • 1
  • Tatsushi Shingai
    • 1
  • Kunihito Gotoh
    • 1
  • Shingo Noura
    • 1
  • Hidenori Takahashi
    • 1
  • Masayuki Ohue
    • 1
  • Terumasa Yamada
    • 1
  • Hiroaki Ohigashi
    • 1
  • Takashi Yamamoto
    • 2
  • Tomoyuki Yamasaki
    • 2
  • Yuichiro Doki
    • 3
  • Osamu Ishikawa
    • 1
  1. 1.Department of SurgeryOsaka Medical Center for Cancer and Cardiovascular DiseasesOsakaJapan
  2. 2.Department of Clinical LaboratoryOsaka Medical Center for Cancer and Cardiovascular DiseasesOsakaJapan
  3. 3.Department of Gastroenterological Surgery, Graduate School of MedicineOsaka UniversityOsakaJapan

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