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Prognostic Value of Perineural Invasion in Patients with Stage II Colorectal Cancer

  • Colorectal Cancer
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Perineural invasion (PNI) may influence the prognosis after resection of colorectal cancer (CRC); whether this is a definite prognostic factor remains controversial. This study determined the clinicopathologic factors associated with oncologic outcome after radical resection of stage II CRC, focusing on PNI.

Materials and Methods

We retrospectively reviewed 341 consecutive patients who underwent curative surgery for stage II CRC between January 2001 and December 2006. Of these, 278 patients (81.5%) received postoperative 5-fluorouracil-based chemotherapy. The oncologic outcomes and the risk factors for recurrence were analyzed.

Results

PNI was detected in 57 of 341 patients (16.7%) and was significantly associated with depth of tumor invasion (P = .035) and positive lymphovascular invasion (P < .001). Multivariate analyses revealed that PNI was a significant independent prognostic factor for disease-free survival, not for overall survival. With a median follow-up period of 57.6 months, the 5-year disease-free and overall survival rates of the patients were 80.2 and 82.6%, respectively. The 5-year disease-free survival of the PNI-negative group was significantly higher than that of the PNI-positive group (P < .001). Within the PNI-positive patients, those receiving chemotherapy had significantly higher 5-year disease-free survival than the others (P = .023).

Conclusion

This study illustrates the value of PNI as a prognostic factor for stage II CRC. Moreover, PNI-positive patients should be considered for postoperative chemotherapy.

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Acknowledgment

This work was supported by a grant from Chonnam National University Research Institute of Medical Sciences and a Research Grant 0720570 from the National Cancer Center, South Korea.

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Authors and Affiliations

  1. Department of Surgery, Chonnam National University Hwasun Hospital and Medical School, Gwangju, Korea

    Jung Wook Huh MD, Hyeong Rok Kim MD & Young Jin Kim MD

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  1. Jung Wook Huh MD
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  2. Hyeong Rok Kim MD
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Correspondence to Hyeong Rok Kim MD.

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Huh, J.W., Kim, H.R. & Kim, Y.J. Prognostic Value of Perineural Invasion in Patients with Stage II Colorectal Cancer. Ann Surg Oncol 17, 2066–2072 (2010). https://doi.org/10.1245/s10434-010-0982-7

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  • DOI: https://doi.org/10.1245/s10434-010-0982-7

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