Annals of Surgical Oncology

, Volume 17, Issue 9, pp 2378–2383 | Cite as

Ki-67 and Bcl-2 Antigen Expression in Adenomatous Colorectal Polyps from Women with Breast Cancer

  • Edílson Carvalho de Sousa-Júnior
  • Airlane Pereira Alencar
  • Benedito Borges da Silva
Breast Oncology

Abstract

Background

The aim of this study was to evaluate Ki-67 and Bcl-2 antigen expression in colorectal polyps from women with breast cancer.

Methods

A randomized, controlled study was carried out in 35 women, either with or without breast cancer, who had adenomatous colorectal polyps. The patients were divided into two groups: group A (without breast cancer; control group; n = 17) and group B (with breast cancer; study group; n = 18). Immunohistochemistry was performed on the colorectal polyps to evaluate Ki-67 and Bcl-2 antigen expression. Student’s t-test and the χ2 test were used for the statistical analysis of Ki-67 and Bcl-2 expression, respectively. Statistical significance was established as P < 0.05.

Results

The mean percentage of Ki-67-stained nuclei in groups A and B was 36.25 ± 2.31 and 59.44 ± 3.34 (± SEM), respectively (P < 0.0001), while the percentage of cases with cells expressing Bcl-2 in groups A and B was 23.5 and 77.8%, respectively (P < 0.001).

Conclusions

In the present study, there was greater proliferative activity and greater expression of the antiapoptotic protein Bcl-2 in the colorectal polyps of women with breast cancer.

Keywords

Breast Cancer Adenoma Lynch Syndrome Adenomatous Polyp Antiapoptotic Protein 

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Copyright information

© Society of Surgical Oncology 2010

Authors and Affiliations

  • Edílson Carvalho de Sousa-Júnior
    • 1
    • 2
  • Airlane Pereira Alencar
    • 3
  • Benedito Borges da Silva
    • 2
  1. 1.Department of General Surgery, Hospital Getulio VargasFederal University of PiauíTeresina, PiauíBrazil
  2. 2.Mastology Division, Department of Gynecology, Hospital Getulio VargasFederal University of PiauíTeresinaBrazil
  3. 3.Department of StatisticsUniversity of São PauloSão PauloBrazil

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