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Survival Analysis of Intrahepatic Cholangiocarcinoma After Resection

  • Hepatobiliary Tumors
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatic malignancy, but the studies for the outcome after resection of ICC are rare. The aim of this study was to elucidate outcomes and prognostic factors of ICC in patients undergoing hepatic resection.

Methods

A retrospective study was conducted with a total of 63 patients who underwent surgical resection with curative intent for ICC. We performed the survival analysis with preoperative and postoperative clinicopathologic factors according to the clinical outcome.

Results

The cumulative 1-, 3-, and 5-year survival rates were 68.2, 50.5, and 31.8%, respectively. Univariate analysis revealed that patient’s old age, high preoperative carbohydrate antigen 19-9 (CA19-9) level, major vessel invasion, T classification, lymph node metastasis, lymphatic invasion, perineural invasion, intrahepatic metastasis, and narrow resection margin were statistically significant. By multivariate analysis, patient’s old age, high preoperative CA19-9 level, lymphatic invasion, and narrow resection margin were independent dismal prognostic factors. The preoperative CA19-9 level shows a significant correlation with some histopathologic factors including major vessel invasion, bile duct invasion, and perineural invasion.

Conclusions

Preoperative CA19-9 level was a valuable clinical factor for predicting histopathologic invasiveness as well as clinical outcome. An adequate resection margin was the only modifiable factor by a surgeon during hepatic resection for ICC.

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Authors and Affiliations

  1. Center for Liver Cancer, National Cancer Center, Goyang-si, Gyeonggi-do, Republic of Korea

    Seong Yeon Cho MD, Sang-Jae Park MD, PhD, Seong Hoon Kim MD, Sung-Sik Han MD, Young-Kyu Kim MD, Kwang-Woong Lee MD, Soon-Ae Lee MD, Eun Kyung Hong MD, Woo Jin Lee MD & Sang Myung Woo MD

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  1. Seong Yeon Cho MD
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  2. Sang-Jae Park MD, PhD
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  3. Seong Hoon Kim MD
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  5. Young-Kyu Kim MD
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Correspondence to Sang-Jae Park MD, PhD.

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Cho, S.Y., Park, SJ., Kim, S.H. et al. Survival Analysis of Intrahepatic Cholangiocarcinoma After Resection. Ann Surg Oncol 17, 1823–1830 (2010). https://doi.org/10.1245/s10434-010-0938-y

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  • DOI: https://doi.org/10.1245/s10434-010-0938-y

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