Proton-Beam, Intensity-Modulated, and/or Intraoperative Electron Radiation Therapy Combined with Aggressive Anterior Surgical Resection for Retroperitoneal Sarcomas
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We sought to reduce local recurrence for retroperitoneal sarcomas by using a coordinated strategy of advanced radiation techniques and aggressive en-bloc surgical resection.
Proton-beam radiation therapy (PBRT) and/or intensity-modulated radiation therapy (IMRT) were delivered to improve tumor target coverage and spare selected adjacent organs. Surgical resection of tumor and adjacent organs was performed to obtain a disease-free anterior margin. Intraoperative electron radiation therapy (IOERT) was delivered to any close posterior margin.
Twenty patients had primary tumors and eight had recurrent tumors. Tumors were large (median size 9.75 cm), primarily liposarcomas and leiomyosarcomas (71%), and were mostly of intermediate or high grade (81%). PBRT and/or IMRT were delivered to all patients, preferably preoperatively (75%), to a median dose of 50 Gy. Surgical resection included up to five adjacent organs, most commonly the colon (n = 7) and kidney (n = 7). Margins were positive for disease, usually posteriorly, in 15 patients (54%). IOERT was delivered to the posterior margin in 12 patients (43%) to a median dose of 11 Gy. Surgical complications occurred in eight patients (28.6%), and radiation-related complications occurred in four patients (14%). After a median follow-up of 33 months, only two patients (10%) with primary disease experienced local recurrence, while three patients (37.5%) with recurrent disease experienced local recurrence.
Aggressive resection of retroperitoneal sarcomas can achieve a disease-negative anterior margin. PBRT and/or IMRT with IOERT may possibly deliver sufficient radiation dose to the posterior margin to control microscopic residual disease. This strategy may minimize radiation-related morbidity and reduce local recurrence, especially in patients with primary disease.
KeywordsPosterior Margin Clinical Target Volume Gross Tumor Volume Malignant Peripheral Nerve Sheath Tumor Soft Tissue Sarcoma
Thomas F. DeLaney received a speaker’s honorarium from IBA Proton Therapy, and David G. Kirsch is a consultant for Guidepoint Global.
- 1.Brennan MF, Lewis JL. Diagnosis and management of soft tissue sarcoma. London: Martin Dunitz; 2002.Google Scholar
- 20.Cox D. Regression models and life-tables. J R Stat Soc. 1972;34:187–220.Google Scholar
- 30.DeLaney TF, Kirsch DG. Bone and soft tissue. In: DeLaney TF, Kooy HM, editors. Proton and charged particle radiotherapy. Philadelphia: Lippincott Williams & Wilkins; 2008. p. 172–85.Google Scholar
- 31.Suit HD, Chu W. History of charged particle radiotherapy. In: DeLaney TF, Kooy HM, editors. Proton and charged particle radiotherapy. Philadelphia: Lippincott Williams & Wilkins; 2008. p. 1–7.Google Scholar
- 32.Pisters PW, Ballo MT, Fenstermacher MJ, et al. Phase I trial of preoperative concurrent doxorubicin and radiation therapy, surgical resection, and intraoperative electron-beam radiation therapy for patients with localized retroperitoneal sarcoma. J Clin Oncol.2003;21:3092–7.CrossRefPubMedGoogle Scholar