Laparoscopic Rectal Resection for Cancer: Effects of Conversion on Short-Term Outcome and Survival

  • Matteo Rottoli
  • Stefano Bona
  • Riccardo Rosati
  • Ugo Elmore
  • Paolo P. Bianchi
  • Antonino Spinelli
  • Cristina Bartolucci
  • Marco Montorsi
Gastrointestinal Oncology

Abstract

Background

Laparoscopic rectal resection (LRR) is an oncologically safe procedure. The impact of conversion to open surgery on outcomes has not been fully elucidated. The aim of the study is to compare short- and long-term outcomes of converted (CR) and not converted (NCR) patients undergoing LRR.

Methods

Data were drawn from a prospective database of LRR performed between 1999 and 2008. Statistical analysis employed the chi-squared or Wilcoxon test and Kaplan–Meier estimation.

Results

Of 173 patients undergoing LRR, 26 (15%) required conversion. No differences in age, gender, American Society of Anesthesiologists (ASA) score, and T and N stages were observed between CR and NCR patients. Conversion was associated with higher body mass index (BMI) (27.3 versus 24.9 kg/m2, P < 0.001) and American Joint Committee on Cancer (AJCC) stage IV (26.9% versus 4.8%, P < 0.001), and resulted in longer operative time (342 versus 285 min, P = 0.006) and increased intraoperative complication rate (31% versus 5%, P < 0.001). No differences were observed in postoperative outcome between CR and NCR patients. After a mean follow-up of 46 and 36 months, 5-year disease-free survival was 55.7% in CR group and 79.2% in NCR group (P = 0.007). After exclusion of stage IV patients from the analysis, 5-year disease-free survival was 71.1% in CR group and 85.3% in NCR group (P = 0.17), while the overall recurrence rate was 26.3% in CR patients and 11.4% in NCR patients (P = 0.07).

Conclusions

Our study suggests that conversion to open surgery does not affect postoperative outcome, but could have a negative impact on long-term overall recurrence rate. LRR should be performed by experienced surgeons in selected patients.

Keywords

Total Mesorectal Excision Oncological Outcome Rectal Resection Circumferential Resection Margin Laparoscopic Total Mesorectal Excision 

Notes

Acknowledgment

The authors thank Elizabeth Corrao for revising the manuscript.

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Copyright information

© Society of Surgical Oncology 2009

Authors and Affiliations

  • Matteo Rottoli
    • 1
  • Stefano Bona
    • 1
  • Riccardo Rosati
    • 2
  • Ugo Elmore
    • 2
  • Paolo P. Bianchi
    • 3
  • Antonino Spinelli
    • 1
  • Cristina Bartolucci
    • 1
  • Marco Montorsi
    • 1
  1. 1.General Surgery IIIUniversity of Milan, Istituto Clinico Humanitas IRCCSRozzano, MilanItaly
  2. 2.General and Minimally Invasive SurgeryUniversity of Milan, Istituto Clinico Humanitas IRCCSRozzano, MilanItaly
  3. 3.Minimally Invasive SurgeryEuropean Institute of Oncology IRCCSMilanItaly

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