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Annals of Surgical Oncology

, Volume 16, Issue 4, pp 979–988 | Cite as

A Contemporary, Population-Based Study of Lymphedema Risk Factors in Older Women with Breast Cancer

  • Tina W. F. Yen
  • Xiaolin Fan
  • Rodney Sparapani
  • Purushuttom W. Laud
  • Alonzo P. Walker
  • Ann B. Nattinger
Breast Oncology

Abstract

Background

We studied potential risk factors for lymphedema in a contemporary population of older breast cancer patients.

Methods

Telephone surveys were conducted among women (65–89 years) identified from Medicare claims as having initial breast cancer surgery in 2003. Lymphedema was classified by self-report. Surgery and pathology information was obtained from Medicare claims and the state cancer registries.

Results

Of 1,338 patients treated by 707 surgeons, 24% underwent sentinel lymph node biopsy (SLNB) and 57% axillary lymph node dissection (ALND). At a median of 48 months postoperatively, 193 (14.4%) had lymphedema. Lymphedema developed in 7% of the 319 patients who underwent SLNB and in 21% of the 759 patients who underwent ALND. When controlling for patient age, tumor size, type of breast cancer, type of breast and axillary surgery, receipt of radiation, chemotherapy, and hormonal therapy, and surgeon case volume, the independent predictors of lymphedema were removal of more than five lymph nodes [odds ratio (OR) 4.68–5.61, 95% confidence interval (CI) 1.36–19.74 for 6–15 nodes; OR 10.50, 95% CI 2.88–38.32 for >15 nodes] and presence of lymph node metastases (OR 1.98, 95% CI 1.21–3.24).

Conclusions

Four years postoperatively, 14% of a contemporary, population-based cohort of elderly breast cancer survivors had self-reported lymphedema. In this group of predominately community-based surgeons, the number of lymph nodes removed is more predictive of lymphedema rather than whether SLNB or ALND was performed. As more women with breast cancer undergo only SLNB, it is essential that they still be counseled on their risk for lymphedema.

Keywords

Sentinel Lymph Node Sentinel Lymph Node Biopsy Breast Cancer Survivor Lymphedema Axillary Lymph Node Dissection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

This research was supported by Grant Numbers K07CA125586 (Dr. Yen) and R01CA81379 (Dr. Nattinger) from the National Institutes of Health/National Cancer Institute.

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Copyright information

© Society of Surgical Oncology 2009

Authors and Affiliations

  • Tina W. F. Yen
    • 1
    • 2
  • Xiaolin Fan
    • 2
    • 3
  • Rodney Sparapani
    • 2
    • 3
  • Purushuttom W. Laud
    • 2
    • 3
  • Alonzo P. Walker
    • 1
  • Ann B. Nattinger
    • 2
    • 4
  1. 1.Division of General SurgeryMedical College of WisconsinMilwaukeeUSA
  2. 2.Center for Patient Care and Outcomes ResearchMedical College of WisconsinMilwaukeeUSA
  3. 3.Division of BiostatisticsMedical College of WisconsinMilwaukeeUSA
  4. 4.Department of MedicineMedical College of WisconsinMilwaukeeUSA

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