Annals of Surgical Oncology

, Volume 15, Issue 4, pp 1224–1231 | Cite as

REG Iα is a Reliable Marker of Chemoradiosensitivity in Squamous Cell Esophageal Cancer Patients

  • Kaori Hayashi
  • Satoru Motoyama
  • Toshihiro Sugiyama
  • Jun-ichi Izumi
  • Akira Anbai
  • Hiroshi Nanjo
  • Hitoshi Watanabe
  • Kiyotomi Maruyama
  • Yoshihiro Minamiya
  • Souichi Koyota
  • Yukio Koizumi
  • Shin Takasawa
  • Katsuyuki Murata
  • Jun-ichi Ogawa
Thoracic Oncology



A reliable marker of chemoradiosensitivity that would enable appropriate and individualized treatment of thoracic squamous cell esophageal cancer has long been sought. We investigated whether regenerating gene (REG) Iα is such a marker.


We assessed expression of REG Iα in untreated endoscopic biopsy specimens and examined the correlation between REG Iα expression and the clinical responses to definitive chemoradiotherapy and prognosis. We also examined the relationship between REG Iα expression in the resected tumor and the prognosis of patients who received esophagectomy for thoracic squamous cell esophageal cancer.


Among the 42 patients treated with definitive chemoradiotherapy, 8 of the 23 REG I-positive patients (35%) showed complete responses to chemoradiotherapy, while only one of the 19 REG I-negative patients did so. The survival rate among the REG I-positive patients was significantly better than among the REG I-negative patients. For the 76 patients treated surgically, there was no significant difference in the survival rates among the REG I-positive and REG I-negative patients.


REG Iα expression in squamous cell esophageal carcinoma may be a reliable marker of chemoradiosensitivity. We anticipate that it will enable us to provide more appropriate and individualized treatment to patients of advanced esophageal squamous cell carcinoma.


Esophageal cancer Chemoradiotherapy REG I Chemoradiosensitivity 


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Copyright information

© Society of Surgical Oncology 2008

Authors and Affiliations

  • Kaori Hayashi
    • 1
    • 2
  • Satoru Motoyama
    • 1
  • Toshihiro Sugiyama
    • 2
  • Jun-ichi Izumi
    • 3
  • Akira Anbai
    • 3
  • Hiroshi Nanjo
    • 4
  • Hitoshi Watanabe
    • 5
  • Kiyotomi Maruyama
    • 1
  • Yoshihiro Minamiya
    • 1
  • Souichi Koyota
    • 2
  • Yukio Koizumi
    • 2
  • Shin Takasawa
    • 6
  • Katsuyuki Murata
    • 7
  • Jun-ichi Ogawa
    • 1
  1. 1.Department of SurgeryAkita University School of MedicineAkitaJapan
  2. 2.Department of BiochemistryAkita University School of MedicineAkitaJapan
  3. 3.Department of RadiologyAkita University School of MedicineAkitaJapan
  4. 4.Department of PathologyAkita University School of MedicineAkitaJapan
  5. 5.Central Research LaboratoryAkita University School of MedicineAkitaJapan
  6. 6.Department of BiochemistryNara Medical UniversityKashiharaJapan
  7. 7.Department of Environmental Health SciencesAkita University School of MedicineAkitaJapan

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