Skip to main content

Advertisement

SpringerLink
Log in

Changes in Pulse Oximetry After Patent Blue Dye Injection Into the Uterine Cervix

  • Gynecologic Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

To evaluate changes in pulse oximetry readings in patients with cervical carcinoma after the injection of patent blue dye into the uterine cervix for sentinel lymph node detection.

Methods

Fifty-six patients underwent radical hysterectomy and bilateral pelvic lymphadenectomy for the treatment of International Federation of Gynecology and Obstetrics stage I or II cervical cancer. Four milliliters of patent blue dye were injected into the cervix. On the eve of surgery, all patients also received an injection of Dextran 500 labeled with technetium 99 m (Tc-99 m Dextran, 600 to 800 μCi) into the cervix and subsequently underwent pelvic lymphoscintigraphy.

Results

Of the 56 patients, 1 (1.79%) had an anaphylactic reaction, and in 13 (23.22%), pulse oximetry readings were <96%. The lowest median pulse oximetry reading in these patients was 87%. Pulse oximetry readings began to decrease between 2 and 10 minutes after patent blue dye injection into the cervix and lasted for approximately 5 minutes. No changes in blood pressure, heart rate, or electrocardiogram were found during the period in which this alteration was recorded by the pulse oximeter.

Conclusion

The decrease in pulse oximetry readings after patent blue dye injection into the cervix was associated with larger tumors and tumors that surrounded the external cervical os.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Vieira SC, Zeferino LC, Silva BB, et al. Estudo do linfonodo sentinela no câncer do colo uterino com azul patente. Rev Assoc Med Bras 2004;50:302–4

    PubMed  Google Scholar 

  2. Massa EC, Grion LF, Ghaname NS. Reação alérgica ao azul patente. Sao Paulo Med J 2005;123:53

    Article  Google Scholar 

  3. Noirot A, Vigneau A, Salengro A, et al. Allergic reaction to patent blue dye for sentinel lymph node detection during uterus oncological surgery. Ann Fr Anesth Reanim 2005;24:541–2

    PubMed  CAS  Google Scholar 

  4. Echt ML, Finan MA, Hoffman MS, et al. Detection of sentinel lymph nodes with lymphazurin in cervical, uterine, and vulvar malignancies. South Med J 1999;92:204–8

    Article  PubMed  CAS  Google Scholar 

  5. van de Lande J, Torrenga B, Raijmakers PG, et al. Sentinel lymph node detection in early stage uterine cervix carcinoma: a systematic review. Gynecol Oncol 2007;106:604–13

    Article  PubMed  Google Scholar 

  6. Koivusalo AM, Von Smitten K, Lindgren L. Sentinel node mapping affects intraoperative pulse oximetric recordings during breast cancer surgery. Acta Anaesthesiol Scand 2002;46:411–4

    Article  PubMed  Google Scholar 

  7. Saito S, Fukura H, Shimada H, et al. Prolonged interference of blue dye “patent blue” with pulse oximetry readings. Acta Anaesthesiol Scand 1995;39:268–9

    Article  PubMed  CAS  Google Scholar 

  8. Hueter L, Schwarzkopf K, Karzai W. Interference of patent blue V dye with pulse oximetry and co-oximetry. Eur J Anaesthesiol 2005;22:475–6

    Article  PubMed  CAS  Google Scholar 

  9. Yusim Y, Livingstone D, Sidi A. Blue dyes, blue people: the systemic effects of blue dyes when administered via different routes. J Clin Anesth 2007;19:315–21

    Article  PubMed  CAS  Google Scholar 

  10. Scheller MS, Unger RJ, Kelner MJ. Effects of intravenously administered dyes on pulse oximetry readings. Anesthesiology 1986;65:550–2

    Article  PubMed  CAS  Google Scholar 

  11. Beenen E, de Roy van Zuidewijn DB. Patients blue on patent blue: an adverse reaction during four sentinel node procedures. Surg Oncol 2005;14:151–4

    Article  PubMed  CAS  Google Scholar 

  12. Mansouri R, Chicken DW, Keshtgar MR. Allergic reactions to patent blue dye. Surg Oncol 2006;5:58

    Article  Google Scholar 

  13. Thierrin L, Steiger D, Zuber JP, Spertini F, Brunisholz Y, Delaloye JF. Severe anaphylactic shock to patent blue V with cardiac arrest during breast carcinoma surgery with lymphatic mapping. Eur J Obstet Gynecol 2007; doi:10.1016/j.ejogrb.2007.09.008

  14. Dewachter P, Mouton-Faivre C, Benhaijoub A, et al. Anaphylactic reaction to patent blue V after sentinel lymph node biopsy. Acta Anaesthesiol Scand 2006;50:245–7

    Article  PubMed  CAS  Google Scholar 

  15. Albo D, Wayne JD, Hunt KK, et al. Anaphylactic reactions to isosulfan blue dye during sentinel lymph node biopsy for breast cancer. Am J Surg 2001;182:393–8

    Article  PubMed  CAS  Google Scholar 

  16. Dewachter P, Mouton-Faivre C, Trechot P, et al. Severe anaphylactic shock with methylene blue instillation. Anesth Analg 2005;101:149–50

    Article  PubMed  Google Scholar 

  17. Stradling B, Aranha G, Gabram S. Adverse skin lesions after methylene blue injections for sentinel lymph node localization. Am J Surg 2002;184:350–2

    Article  PubMed  Google Scholar 

  18. Keller B, Yawalkar N, Pichler C, et al. Hypersensitivity reaction against patent blue during sentinel lymph node removal in three melanoma patients. Am J Surg 2007;193:122–4

    Article  PubMed  Google Scholar 

  19. Tobin MJ. Principles and Practice of Intensive Care Monitoring. New York: McGraw Hill, 1998

  20. Loar PV 3rd, Reynolds RK. Sentinel lymph node mapping in gynecologic malignancies. Int J Gynaecol Obstet 2007;99:69–74

    Article  PubMed  Google Scholar 

  21. Schneider A. The sentinel concept in patients with cervical cancer. J Surg Oncol 2007;96:337–41

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Universidade Federal do Piauí (UFPI), Rua Félix Pacheco 2159, Sala 305, Edifício Shecap, 64001-160, Teresina, Piauí, Brazil

    Sabas Carlos Vieira MD, Rodrigo Beserra Sousa, Marília Buenos Aires Cabral Tavares & Alexandra Kolontai de Sousa Oliveira MD

  2. São Marcos Hospital, Teresina, Brazil

    Sabas Carlos Vieira MD, Benedita Andrade Leal de Abreu PhD & Jerúsia Oliveira Ibiapina MD

  3. Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil

    Luiz Carlos Zeferino PhD

Authors
  1. Sabas Carlos Vieira MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rodrigo Beserra Sousa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Marília Buenos Aires Cabral Tavares
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Benedita Andrade Leal de Abreu PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jerúsia Oliveira Ibiapina MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Alexandra Kolontai de Sousa Oliveira MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Luiz Carlos Zeferino PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sabas Carlos Vieira MD.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vieira, S.C., Sousa, R.B., Tavares, M.B.A.C. et al. Changes in Pulse Oximetry After Patent Blue Dye Injection Into the Uterine Cervix. Ann Surg Oncol 15, 2862–2866 (2008). https://doi.org/10.1245/s10434-008-0089-6

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1245/s10434-008-0089-6

Keywords

Search

Navigation