Annals of Surgical Oncology

, Volume 15, Issue 7, pp 2066–2067 | Cite as

Botulinum Toxin: A Novel Adjuvant for Giant Cell Tumor

Bone and Soft Tissue Sarcomas


Botulinum Toxin Giant Cell Tumor Giant Cell Tumor Osteoclast Precursor Clostridium Botulinum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Puri A, Agrawal MG, Shah M, et al. Giant cell tumor of bone in children and adolescents. J Pediatr Orthop 2007;27:635–9PubMedGoogle Scholar
  2. 2.
    Maki K, Harada T, Akiyami Y, et al. Giant cell tumor of the rib. Intern Med 2007;46:1151–2PubMedCrossRefGoogle Scholar
  3. 3.
    Kapoor SK, Jain V, Agrawal M, et al. Primary malignant giant cell tumor of bone: a series of three rare cases. J Surg Orthop Adv 2007;16:89–92PubMedGoogle Scholar
  4. 4.
    Gleason BC, Kleinman PK, Debelenko LV, et al. Novel karyotypes in giant cell-rich lesions of bone. Am J Surg Pathol 2007;31:926–32PubMedCrossRefGoogle Scholar
  5. 5.
    Jones KB, DeYoung BR, Morcuende JA, et al. Ethanol as a local adjuvant for giant cell tumor of bone. Iowa Orthop J 2006;26:69–76PubMedCrossRefGoogle Scholar
  6. 6.
    Turcotte RE. Giant cell tumor of bone. Orthop Clin North Am 2006;37:35–51PubMedCrossRefGoogle Scholar
  7. 7.
    Werner M. Giant cell tumour of bone: morphological, biological and histogenetical aspects. Int Orthop 2006;30:484–9PubMedCrossRefGoogle Scholar
  8. 8.
    Hu Y, Yu S. Gene expression of osteoprotegerin and osteoclast differentiation factor in giant cell tumor. Zhonghua Bing Li Xue Za Zhi 2002;31:128–31PubMedGoogle Scholar
  9. 9.
    Atkins GJ, Kostakis P, Vincent C, et al. RANK Expression as a cell surface marker of human osteoclast precursors in peripheral blood, bone marrow, and giant cell tumors of bone. J Bone Miner Res 2006;21:1339–49PubMedCrossRefGoogle Scholar
  10. 10.
    Hirai F, Nakayamada S, Okada Y, et al. Small GTPase Rho signaling is involved in beta1 integrin-mediated up-regulation of intercellular adhesion molecule 1 and receptor activator of nuclear factor kappaB ligand on osteoblasts and osteoclast maturation. Biochem Biophys Res Commun 2007;356:279–85PubMedCrossRefGoogle Scholar
  11. 11.
    Desai B, Rogers MJ, Chellaiah MA. Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells. Mol Cancer 2007;6:18–21PubMedCrossRefGoogle Scholar
  12. 12.
    Brazier H, Stephens S, Ory S, et al. Expression profile of RhoGTPases and RhoGEFs during RANKL-stimulated osteoclastogenesis: identification of essential genes in osteoclasts. J Bone Miner Res 2006;21:1387–98PubMedCrossRefGoogle Scholar
  13. 13.
    Holbourn KP, Sutton JM, Shore C, et al. Molecular recognition of an ADP-ribosyl transferase; clostridium botulinum C3 exoenzyme. Proc Natl Acad Sci 2005;102:5357–62PubMedCrossRefGoogle Scholar
  14. 14.
    Harmey D, Stenbeck G, Nobes CD, et al. Regulation of osteoblast differentiation by Pasteurella multocida toxin (PMT): a role for Rho GTPase in bone formation. J Bone Miner Res 2004;19:661–7PubMedCrossRefGoogle Scholar
  15. 15.
    Singh R, Wang B, Shirraikar A, et al. The IL-1 receptor and Rho directly associate to drive cell activation in inflammation. J Clin Invest 1999;103:1561–70PubMedCrossRefGoogle Scholar

Copyright information

© Society of Surgical Oncology 2007

Authors and Affiliations

  1. 1. Department of Orthopaedic SurgeryShiraz University of Medical SciencesShirazIslamic Republic of Iran
  2. 2.Chamran Hospital-Shiraz-IranShirazIslamic Republic of Iran

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