Annals of Surgical Oncology

, Volume 15, Issue 4, pp 972–978 | Cite as

Early Hepatocellular Carcinoma: Pathology, Imaging, and Therapy

  • Tadatoshi Takayama
  • Masatoshi Makuuchi
  • Masamichi Kojiro
  • Gregory Y. Lauwers
  • Reid B. Adams
  • Stephanie R. Wilson
  • Hyun-Jung Jang
  • Chusilp Charnsangavej
  • Bachir Taouli
Hepatic and Pancreatic Tumors



In 1987, Japanese researchers proposed to define the pathological concept of early hepatocellular carcinoma (HCC). However, there are some conceptual differences between the East and the West in the diagnosis and treatment of early HCC.


To provide up-to-date data for making a worldwide consensus, this article has collected six papers focused on the management of early HCC, which were presented in the Fifth International Meeting of “Hepatocellular Carcinoma: Eastern and Western Experiences” in Houston in January 2007.


In the pathological perspective, the common criteria to discriminate early HCC from dysplastic nodule included hepatocytic invasion of portal triads and septa (stromal invasion). The current imaging modalities such as contrast-enhanced ultrasound (CEUS), computed tomography (CT), and magnetic resonance imaging (MRI) with the use of intravenous contrast material with multiphasic imaging could enhance their ability to accurately characterize early HCC. From the treatment perspective, a single early HCC had a high chance for cure by resection, ablation, or transplantation, which proved to be the earliest clinical entity (Stage 0 HCC).


Early HCC is characterized by its incipient malignant nature and by an extremely favorable clinical outcome, thereby justifying its definition.


Hepatocellular carcinoma Early HCC Pathology Imaging Therapy 


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Copyright information

© Society of Surgical Oncology 2007

Authors and Affiliations

  • Tadatoshi Takayama
    • 1
  • Masatoshi Makuuchi
    • 2
  • Masamichi Kojiro
    • 3
  • Gregory Y. Lauwers
    • 4
  • Reid B. Adams
    • 5
  • Stephanie R. Wilson
    • 6
  • Hyun-Jung Jang
    • 6
  • Chusilp Charnsangavej
    • 7
  • Bachir Taouli
    • 8
  1. 1.Department of Digestive SurgeryNihon University School of MedicineTokyoJapan
  2. 2.Department of Surgery, Graduate School of MedicineUniversity of TokyoTokyoJapan
  3. 3.Department of PathologyKurume University School of MedicineKurumeJapan
  4. 4.Department of PathologyMassachusetts General Hospital, Harvard Medical SchoolBostonUSA
  5. 5.Department of SurgeryUniversity of VirginiaCharlottesvilleUSA
  6. 6.Department of Medical ImagingUniversity of TorontoTorontoCanada
  7. 7.Department of RadiologyThe University of Texas MD Anderson Cancer CenterHoustonUSA
  8. 8.Department of RadiologyNew York UniversityNew YorkUSA

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