Annals of Surgical Oncology

, Volume 14, Issue 8, pp 2173–2174 | Cite as

SEER Data: It Can Be Thought Provoking, But Where Do We Go From Here?

  • Nicholas J. Petrelli

This editorial will more than likely be the shortest in the history of Annals of Surgical Oncology. The article discussed is by Gnerlich et al., entitled “Surgical Removal of the Primary Tumor Increases Overall Survival in Patients with Metastatic Breast Cancer: Analysis of the 1988–2003 SEER Data.” The reason for the short editorial is that the authors do an outstanding job of discussing the limitations of their data source.

The bottom line in this manuscript is that patients with first primary stage-IV breast cancer at the time of diagnosis, who were enrolled in the Surveillance, Epidemiology, and End Results (SEER) program between 1988 and 2003, had a significant survival advantage following surgical removal of the primary breast tumor compared with women who did not undergo surgery. Following the control for demographic and clinical factors associated with survival in univariate tests and propensity scores, women with metastatic breast cancer were 37% less likely to die during the...


  1. 1.
    Khan SA, Stewart AK, Morrow M. Does aggressive local therapy improve survival in metastatic breast cancer? Surgery 2002; 132:620–627PubMedCrossRefGoogle Scholar
  2. 2.
    Babiera GV, Rao R, Feng L, et al. Effect of primary tumor extirpation in breast cancer patients who present with stage IV disease and an intact primary tumor. Ann Surg Oncol 2006; 13(6):776–782PubMedCrossRefGoogle Scholar
  3. 3.
    Rapiti E, Verkooijen HM, Vlastos G, et al. Complete excision of primary breast tumor improves survival of patients with metastatic breast cancer at diagnosis. J Clin Oncol 2006; 24:2743–2749PubMedCrossRefGoogle Scholar
  4. 4.
    Retsky M, BonadonnaG, Demicheli R, Folkman J, Hrushesky W, Valagussa P. Hypothesis: induced angiogenesis after surgery in premenopausal node-positive breast cancer patients is a major underlying reason why adjuvant chemotherapy works particularly well for those patients. Breast Cancer Res 2004; 6:R372–R374PubMedCrossRefGoogle Scholar
  5. 5.
    Danna EA, Sinha P, Gilbert M, et al. Surgical removal of the primary tumor reverses tumor-induced immunosuppression despite the presence of metastatic disease. Cancer Res 2004; 64:2205–2211PubMedCrossRefGoogle Scholar

Copyright information

© Society of Surgical Oncology 2007

Authors and Affiliations

  1. 1.Helen F. Graham Cancer Center at Christiana Care Health ServicesNewarkUSA

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