Tattooing Breast Cancers Treated with Neoadjuvant Chemotherapy
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In breast carcinomas treated with neoadjuvant chemotherapy, intraoperative identification of residual tumors may be difficult. A well-tolerated, low-diffusion charcoal suspension has been designed to tattoo breast tumors. In this study, we investigated whether this tattooing technique is efficient for localizing the tumor after treatment with chemotherapy.
In a series of 109 patients with large breast tumors, a 4% or 10% charcoal suspension was injected at the time of the initial biopsy before preoperative chemotherapy.
Tolerance was good. After three or four cycles of chemotherapy, 91 patients underwent conservative treatment, and the surgical specimen was examined intraoperatively. The charcoal was detected in 94% of the cases. The charcoal was seen in the nodule or at the periphery in the surgical specimen without any acute inflammatory reaction or diffusion.
On the basis of these results, this micronized charcoal suspension at a defined granulometry and a concentration of 10% seems to be ideal for tattooing breast carcinomas over a period of 3 months in patients in whom neoadjuvant chemotherapy is planned.
KeywordsBreast cancer Charcoal suspension In vivo labeling Neoadjuvant chemotherapy
We thank Lorna Saint Ange for editing.
- 3.Czarnecki DJ, Feider HK, Splittgerber GF. Toluidine blue dye as a breast localization marker. Am J Roentgenol 1989; 261–3Google Scholar
- 5.Svane GA. Stereotaxic techniques for preoperative marking of non palpable breast lesions. Acta Radiol Diagn 1983; 24:145–51Google Scholar
- 6.Baron LF, Baron PL, Ackerman SJ, Durden DD, Pope TL Jr. Sonographically guided clip placement facilitates localization of breast cancer after neoadjuvant chemotherapy. Am J Roentgenol 2000; 174:539–40Google Scholar
- 11.Svane G. A stereotaxic technique for preoperative marking of non palpable breast lesions. Acta Radiol Diagn 1983; 24:145–51Google Scholar
- 15.US Pharmacopeia. 22nd rev ed. Easton, PA: Mack Publishing, 1991:1483–7Google Scholar
- 16.US Pharmacopeia. 22nd rev ed. Easton, PA: Mack Publishing, 1991:1493–5Google Scholar