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Annals of Surgical Oncology

, Volume 14, Issue 8, pp 2233–2238 | Cite as

Tattooing Breast Cancers Treated with Neoadjuvant Chemotherapy

  • Marie-Christine Mathieu
  • Laurence Bonhomme-Faivre
  • Roman Rouzier
  • Monique Seiller
  • Lise Barreau-Pouhaer
  • Jean-Paul Travagli
Article

Abstract

Background

In breast carcinomas treated with neoadjuvant chemotherapy, intraoperative identification of residual tumors may be difficult. A well-tolerated, low-diffusion charcoal suspension has been designed to tattoo breast tumors. In this study, we investigated whether this tattooing technique is efficient for localizing the tumor after treatment with chemotherapy.

Methods

In a series of 109 patients with large breast tumors, a 4% or 10% charcoal suspension was injected at the time of the initial biopsy before preoperative chemotherapy.

Results

Tolerance was good. After three or four cycles of chemotherapy, 91 patients underwent conservative treatment, and the surgical specimen was examined intraoperatively. The charcoal was detected in 94% of the cases. The charcoal was seen in the nodule or at the periphery in the surgical specimen without any acute inflammatory reaction or diffusion.

Conclusions

On the basis of these results, this micronized charcoal suspension at a defined granulometry and a concentration of 10% seems to be ideal for tattooing breast carcinomas over a period of 3 months in patients in whom neoadjuvant chemotherapy is planned.

Keywords

Breast cancer Charcoal suspension In vivo labeling Neoadjuvant chemotherapy 

Notes

Acknowledgment

We thank Lorna Saint Ange for editing.

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Copyright information

© Society of Surgical Oncology 2007

Authors and Affiliations

  • Marie-Christine Mathieu
    • 1
  • Laurence Bonhomme-Faivre
    • 2
  • Roman Rouzier
    • 3
  • Monique Seiller
    • 4
  • Lise Barreau-Pouhaer
    • 5
  • Jean-Paul Travagli
    • 5
  1. 1.Department of Pathology Institut Gustave-RoussyVillejuifFrance
  2. 2.Laboratory of PharmacyHôpital Paul-BrousseVillejuifFrance
  3. 3.Department of SurgeryHôpital Henri MondorCréteilFrance
  4. 4.Laboratory of Pharmaceutical TechnologyFaculté de MédecineCaenFrance
  5. 5.Department of SurgeryInstitut Gustave-RoussyVillejuifFrance

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