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Annals of Surgical Oncology

, Volume 13, Issue 4, pp 533–541 | Cite as

Predictors of Regional Nodal Disease in Patients With Thin Melanomas

  • Giorgos C. Karakousis
  • Phyllis A. Gimotty
  • Jeffrey D. Botbyl
  • Susan B. Kesmodel
  • David E. Elder
  • Rosalie Elenitsas
  • Michael E. Ming
  • DuPont Guerry
  • Douglas L. Fraker
  • Brian J. Czerniecki
  • Francis R. Spitz
Article

Abstract

Background

Most melanoma patients present with thin (≤1.0 mm) lesions. Indications for sentinel lymph node (SLN) biopsy are not well defined for this group. Previously, we reported an association between mitotic rate (MR) and SLN positivity in these patients. The study was limited by a relatively small sample size and low statistical power. In this study, we evaluated a large population of patients with thin melanoma from the pre-SLN era to identify predictors of regional nodal disease (RND) that may serve as a surrogate for SLN positivity.

Methods

Eight hundred eighty-two patients evaluated between 1972 and 1991 were included in the study. Univariate and multivariate regression analyses were performed by using clinical and histological data to identify factors associated with RND. A multivariate logistic regression model was developed and applied to the previously reported group of patients with thin melanomas who underwent SLN biopsy between 1996 and 2004 for validation.

Results

Thirty-eight patients (4.3%) had evidence of RND. In the multivariate analysis, a MR >0, vertical growth phase (VGP), male sex, and ulceration were statistically significant predictors of RND. Patients at the highest risk according to a classification tree analysis (VGP and MR >0) had an RND rate of 11.9%. The regression model developed predicted well the SLN status in the validation sample.

Conclusions

Investigation of a large pre-SLN population identified MR >0, ulceration, VGP, and male sex as independently predictive of RND in patients with thin melanomas. These factors may help to identify subgroups of these patients that have clinically significant risks of SLN positivity.

Keywords

Thin melanomas Regional nodal disease Mitotic rate Ulceration Vertical growth phase 

Notes

Acknowledgments

This study was supported in part by the SPORE on Skin Cancer (CA-093372; M. Herlyn, principal investigator). The authors thank all of the patients who were seen at the Pigmented Lesion Clinic (PLC) and gave their consent for use of their data for research studies, as well as the investigators (W. H. Clark, Jr, MD [deceased], E. E. Bondi, MD, L. P. Bucky, MD, L. S. Callans, MD, B. Chang, MD, K. T. Flaherty, MD, A. C. Halpern, MD, R. Hamilton, MD, D. Hershock, MD, D. D. Larossa, MD, S. R. Lessin, MD, D. Low, MD, P. Van Belle, MD, and J. Wolfe, MD) and staff (R. Holmes, S. Hotz, N. Lowden, I. Matozzo, M. Price, M. Synnestvedt, and J. Thompson) of the PLC for their contributions over the last three decades to the Melanoma Core Database on which this report is based.

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Copyright information

© The Society of Surgical Oncology, Inc. 2006

Authors and Affiliations

  • Giorgos C. Karakousis
    • 1
  • Phyllis A. Gimotty
    • 2
    • 6
  • Jeffrey D. Botbyl
    • 2
  • Susan B. Kesmodel
    • 1
  • David E. Elder
    • 3
    • 6
  • Rosalie Elenitsas
    • 4
    • 6
  • Michael E. Ming
    • 4
    • 6
  • DuPont Guerry
    • 5
    • 6
  • Douglas L. Fraker
    • 1
    • 6
  • Brian J. Czerniecki
    • 1
  • Francis R. Spitz
    • 1
    • 6
    • 7
  1. 1.Department of SurgeryUniversity of Pennsylvania Health System, Abramson Cancer CenterPhiladelphia
  2. 2.Department of Biostatistics and EpidemiologyUniversity of Pennsylvania Health System, Abramson Cancer CenterPhiladelphia
  3. 3.Department of Pathology and Laboratory MedicineUniversity of Pennsylvania Health System, Abramson Cancer CenterPhiladelphia
  4. 4.Department of DermatologyUniversity of Pennsylvania Health System, Abramson Cancer CenterPhiladelphia
  5. 5.Department of Medicine, Division of Hematology and OncologyUniversity of Pennsylvania Health System, Abramson Cancer CenterPhiladelphia
  6. 6.The Pigmented Lesion Group and the Melanoma ProgramUniversity of Pennsylvania Health System, Abramson Cancer CenterPhiladelphia
  7. 7.Division of Endocrine and Oncologic SurgeryHospital of the University of PennsylvaniaPhiladelphia

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