Annals of Surgical Oncology

, Volume 13, Issue 1, pp 75–85 | Cite as

Solitary and Multiple Isolated Metastases of Clear Cell Renal Carcinoma to the Pancreas: An Indication for Pancreatic Surgery

  • Franz Sellner
  • Natascha Tykalsky
  • Maria De Santis
  • Jörg Pont
  • M. Klimpfinger
Original Article

Abstract

Background

Isolated pancreatic metastases (isPMs) of clear cell renal carcinoma are rare. Most of them are solitary; some are multiple. The reported rates and the clinical implications of multiple isPMs from clear cell renal cancer vary. Therefore, the available literature was analyzed to shed light on the clinical significance of these extremely rare metastatic lesions.

Methods

A literature search brought to light 236 cases of isPMs (both solitary and multiple) from renal cell carcinoma. These were analyzed.

Results

A total of 12% of the metastases were synchronous with the primary tumor, and 88% were metachronous, occurring 10.0 ± 6.5 years (mean ± SD) after nephrectomy. A predilection for a specific part of the pancreas was not identifiable. The localization of the renal cell cancer (left or right kidney) did not have any effect on the site of the metastases. Seventy-four (39%) of the metastases to the pancreas were multiple (3.2 ± 1.5). Their epidemiology did not differ from that of solitary metastatic lesions. Actuarial 3- and 5-year survival rates after radical resection were 78% and 78%, respectively, for multiple versus 75% and 64% for solitary metastases.

Conclusions

The epidemiological data do not support a direct local lymphogenous or venous spread from the primary tumor to the pancreas. They rather suggest a systemic spread. Because of the positive outcome, radical removal of both solitary and multiple metastases should be attempted in eligible patients.

Keywords

Solitary/multiple pancreatic metastases Renal carcinoma Epidemiology Prognosis 

Notes

Acknowledgments

The authors thank Dr. J. Karner, head of the Department of Surgery of Kaiser Franz Josef Hospital, for providing cases 2 and 3 from the surgery database.

References

  1. 1.
    Mehta N, Volpe C, Haley T, Balos L, Bradley E, Doerr R. Pancreaticoduodenectomy for metastatic renal cell carcinoma: report of a case. Surg Today 2000;30:94–7PubMedGoogle Scholar
  2. 2.
    Marusch F, Koch A, Dietrich F, Hoschke B, Gastinger I. Singular late metastasis of renal cell carcinoma in the pancreas. An unusual pancreatic tumor. Zentralbl Chir 2001;126:391–5PubMedCrossRefGoogle Scholar
  3. 3.
    Robbins E, Franceschi D, Barkin J. Solitary metastatic tumors to the pancreas: a case report, review of the literature. Am J Gastroenterol 1997;92:914–5Google Scholar
  4. 4.
    Giulini S, Portolani N, Bonardelli S, et al. Distal pancreatic resection with splenic preservation for metastasis of renal carcinoma diagnosed 24 years later from nephrectomy. Ann Ital Chir 2003;74:93–6PubMedGoogle Scholar
  5. 5.
    Hernandez D, Kavoussi I, Eleison L. Laparoscopic distal pancreatectomy for metastatic renal cell carcinoma. Urology 2003;62:551PubMedCrossRefGoogle Scholar
  6. 6.
    Law C, Wei A, Hanna S, et al. Pancreatic resection for metastatic renal cell carcinoma: presentation, treatment and outcome. Ann Surg Oncol 2003;10:922–6PubMedCrossRefGoogle Scholar
  7. 7.
    Nakagohri T, Konoshi M, Inoue K, Nakamura T, Kinoshita T. Partial pancreatic head resection for pancreatic metastasis from renal cell carcinoma. Hepatogastroenterology 2003;50:2236–8PubMedGoogle Scholar
  8. 8.
    Pecchi A, Cesinaro A, Torricelli P. Solitary pancreatic metastasis from renal cell carcinoma. A case report. Radiol Med 2003;105:386–90PubMedGoogle Scholar
  9. 9.
    Uemura T, Kurita A, Nishimura R, Ishizaki M, Takashima S. Solitary pancreatic metastasis from renal cell carcinoma concomitant with early gastric cancer 17 years after nephrectomy. Report of a case. Surg Today 2003;33:395–8PubMedCrossRefGoogle Scholar
  10. 10.
    Bechade D, Palazzo I, Desrame J, et al. Pancreatic metastasis of renal carcinoma: report of three cases. Rev Med Interne 2002;23:862–6PubMedGoogle Scholar
  11. 11.
    Chou Y, Chiou H, Hong T, et al. Solitary metastasis from renal cell carcinoma presenting as diffuse pancreatic enlargement. J Clin Ultrasound 2002;30:499–502PubMedCrossRefGoogle Scholar
  12. 12.
    Eloubeidi M, Jhala D, Chhieng D, Jhala N, Eltoum I, Wilcox C. Multiple late asymptomatic pancreatic metastases from renal cell carcinoma: diagnosis by endoscopic ultrasound-guided fine needle aspiration biopsy with immunocytochemical correlation. Dig Dis Sci 2002;47:1839–42PubMedCrossRefGoogle Scholar
  13. 13.
    Hiotis S, Klimstra D, Conlon K, Brennan M. Results after pancreatic resection for metastatic lesions. Ann Surg Oncol 2002;9:675–9PubMedCrossRefGoogle Scholar
  14. 14.
    Lisii D, Gainant A, Sautereau D, Paraf F, Maubon A. Duodenal bleeding revealing a renal cell carcinoma. Gastroenterol Clin Biol 2002;26:1044–6PubMedGoogle Scholar
  15. 15.
    Peschaud F, Cheynel N, Hagry O, Tremeaux J, Rat P, Favre J. Surgical treatment of pancreatic metastases from renal carcinoma. Ann Chir 2002;127:527–31PubMedCrossRefGoogle Scholar
  16. 16.
    Roviello F, Nastri G, Hako L, Marrelli D, De Stefano A, Cioppa T. Pancreatic metastasis from clear renal cell carcinoma: a clinical case. Chir Ital 2002;54:873–7PubMedGoogle Scholar
  17. 17.
    Yachida S, Fukushima N, Kanai Y, et al. Pancreatic metastasis from renal cell carcinoma extending into the main pancreatic duct: a case report. Jpn J Clin Oncol 2002;32:315–7PubMedCrossRefGoogle Scholar
  18. 18.
    Espinoza R, Rossi R, Rossi R, Rosenberg H. Metachronous pancreatic metastasis of a renal cell carcinoma: 3 new cases. Rev Med Chil 2001;129:86–90PubMedGoogle Scholar
  19. 19.
    Faure JP, Tuech J, Richer J, Pessaux P, Arnaud J, Carretier M. Pancreatic metastasis of renal cell carcinoma: presentation, treatment and survival. J Urol 2001;165:20–2PubMedCrossRefGoogle Scholar
  20. 20.
    Hashimoto M, Miura Y, Matsuda M, Watanabe G. Concomitant duodenal and pancreatic metastases from renal cell carcinoma: report of a case. Surg Today 2001;31:180–3PubMedGoogle Scholar
  21. 21.
    Ruibal Moldes M, Quintana de la Rosa J, Farina Perez L, Tardaguila F, Ortiz Rey J, Zungri Telo E. Late pancreatic metastasis from renal carcinoma. Actas Urol Esp 2001;25:122–4PubMedGoogle Scholar
  22. 22.
    Scatarige J, Horton K, Sheth S, Fishman E. Pancreatic parenchymal metastases: observations on helical CT. AJR Am J Roentgenol 2001;176:695–9PubMedGoogle Scholar
  23. 23.
    Sohn T, Yeo C, Cameron J, Nakeeb A, Lillemoe K. Renal cell carcinoma metastatic to the pancreas: results of surgical management. J Gastrointest Surg 2001;5:346–51PubMedGoogle Scholar
  24. 24.
    Tada T, Kobayashi G, Noda Y, Kimura K, Ito K, Fujita N. A resected case with multiple pancreatic metastasis of renal cell carcinoma. Nippon Shokakibyo Gakkai Zasshi 2001;98:1368–73PubMedGoogle Scholar
  25. 25.
    Fricke P, Schulz HU, Buhtz B, Lippert H. Multiple metachrone Metastasen eines Nierenzellkarzinoms im Pankreas. Fallbeschreibung und Literaturübersicht. Chirurg 2000;71:575–9Google Scholar
  26. 26.
    Ghavamian R, Klein K, Stephens D, et al. Renal cell carcinoma metastatic to the pancreas: clinical and radiological features. Mayo Clin Proc 2000;75:581–5PubMedCrossRefGoogle Scholar
  27. 27.
    Kassabian A, Stein J, Jabbour N, et al. Renal cell carcinoma metastatic to the pancreas: a single institution series and review of the literature. Urology 2000;56:211–5PubMedCrossRefGoogle Scholar
  28. 28.
    Le Borgne J, Partensky C, Glemain P, Dupas B, de Kerviller B. Pancreaticoduodenectomy for metastatic ampullary and pancreatic tumors. Hepatogastroenterology 2000;47:540–4PubMedGoogle Scholar
  29. 29.
    Thompson L, Heffess C. Renal cell carcinoma to the pancreas in surgical pathology material. A clinicopathological study with 21 cases with a review of the literature. Cancer 2000;89:1076–88PubMedCrossRefGoogle Scholar
  30. 30.
    Augustin H, Bacher H, Uggowitzer M, Ott A, Hubmer G, Mischinger H. Pancreatic metastases from renal cell carcinoma mimicking insulinomas. BJU Int 1999;83:140–1PubMedCrossRefGoogle Scholar
  31. 31.
    Carucci L, Siegelman E, Feldman M. Pancreatic metastasis from clear cell renal carcinoma: diagnosis with chemical shift MRI. J Comput Assist Tomogr 1999;23:934–6PubMedCrossRefGoogle Scholar
  32. 32.
    Eriguchi N, Aoyagi S, Hara M, et al. A resected case of pancreatic metastasis from primary renal cell carcinoma. Kurume Med J 1999;46:119–22PubMedGoogle Scholar
  33. 33.
    Ng CS, Loyer E, Iyer R, David C, DuBrow R, Charnsangavej C. Metastases to the pancreas from renal cell carcinoma: findings on three-phase contrast-enhanced helical CT. AJR Am J Roentgenol 1999;172:1555–9PubMedGoogle Scholar
  34. 34.
    Sugiyama M, Katsura M, Yamamoto K, et al. Pancreatic metastasis from renal cell carcinoma causing massive gastrointestinal bleeding in von Hippel-Lindau disease. Hepatogastroenterology 1999;46:1199–201PubMedGoogle Scholar
  35. 35.
    Yavascaoglu I, Korun N, Oktay B, Simsek U, Ozyurt M. Renal cell carcinoma with solitary synchronous pancreaticoduodenal and metachronous periprostatic metastases: report of a case. Surg Today 1999;29:364–6PubMedCrossRefGoogle Scholar
  36. 36.
    Adem C, Chetritt J, Guymar S, et al. Pancreatic metastasis of a renal adenocarcinoma. Apropos of 2 cases. Ann Pathol 1998;18:481–3PubMedGoogle Scholar
  37. 37.
    Altschuler E, Ray A. Spontaneous regression of a pancreatic metastasis of a renal cell carcinoma. Arch Fam Med 1998;7:516–7PubMedCrossRefGoogle Scholar
  38. 38.
    Butturini G, Bassi C, Falconi M, et al. Surgical treatment of pancreatic metastases from renal cell carcinomas. Dig Surg 1998;15:241–6PubMedCrossRefGoogle Scholar
  39. 39.
    Gupta R, Lallu S, Delahunt B. Fine-needle aspiration cytology of metastatic clear-cell renal carcinoma presenting as a solitary mass in the head of the pancreas. Diagn Cytopathol 1998;19:194–7PubMedGoogle Scholar
  40. 40.
    Hashimoto M, Watanabe G, Matsuda M, Dohi T, Tsurumaru M. Management of pancreatic metastases from renal cell carcinoma: report of four resected cases. Hepatogastroenterology 1998;45:1150–4PubMedGoogle Scholar
  41. 41.
    Jingu K, Watanabe K, Yamamoto H, et al. Surgical treatment of a solitary pancreatic metastasis from renal cell carcinoma: report of a case. Surg Today 1998;28:91–4PubMedCrossRefGoogle Scholar
  42. 42.
    Merkle E, Boaz T, Kolokythas O, Haaga J, Lewin J, Brambs H. Metastases to the pancreas. Br J Radiol 1998;71:1208–14PubMedGoogle Scholar
  43. 43.
    Sahin M, Foulis A, Poon F, Imrie C. Late focal pancreatic metastasis of renal cell carcinoma. Dig Surg 1998;15:72–4PubMedCrossRefGoogle Scholar
  44. 44.
    Z’graggen K, Fernandez-del Castillo C, Rattner D, Sigala H, Warshaw A. Metastases to the pancreas and their surgical extirpation. Arch Surg 1998;133:413–7PubMedGoogle Scholar
  45. 45.
    Chambers T, Fishman E, Hruban R. Pancreatic metastases from renal cell carcinoma in von Hippel-Lindau disease. Clin Imaging 1997;21:40–2PubMedCrossRefGoogle Scholar
  46. 46.
    Harrison L, Merchant N, Cohen A, Brennan M. Pancreaticoduodenectomy for nonperiampullary primary tumors. Am J Surg 1997;174:393–5PubMedCrossRefGoogle Scholar
  47. 47.
    Zhao B, Kimura W, Futakawa N, Muto T, Haida K. Renal cell carcinoma of the spindle cell type with metastasis to the pancreas: a case report. Jpn J Clin Oncol 1997;27:58–61PubMedCrossRefGoogle Scholar
  48. 48.
    Barras JP, Baer H, Stenzl A, Czerniak A. Isolated late metastasis of a renal cell cancer treated by radical distal pancreatectomy. HPB Surg 1996;10:51–3PubMedGoogle Scholar
  49. 49.
    Hirota T, Tomida T, Iwasa M, Takahashi K, Kaneda M, Tamaki H. Solitary pancreatic metastasis occurring eight years after nephrectomy for renal cell carcinoma. A case report and surgical review. Int J Pancreatol 1996;19:145–53PubMedGoogle Scholar
  50. 50.
    Palazzo L, Borotto E, Cellier C, et al. Endosonographic features of pancreatic metastases. Gastrointest Endosc 1996;44:433–6PubMedCrossRefGoogle Scholar
  51. 51.
    Paz A, Koren R, Gal R, Wolloch Y. Late solitary pancreatic metastasis from renal cell carcinoma. Isr J Med Sci 1996;32:1319–21PubMedGoogle Scholar
  52. 52.
    Dousset B, Andant C, Guimbaud R, et al. Late pancreatic metastasis from renal cell carcinoma diagnosed by endoscopic ultrasonography. Surgery 1995;117:591–4PubMedGoogle Scholar
  53. 53.
    Fabre JM, Rouanet P, Dagues F, Blanc F, Baumel H, Domergue J. Various features and surgical approach of solitary pancreatic metastasis from renal cell carcinoma. Eur J Surg Oncol 1995;21:683–6PubMedGoogle Scholar
  54. 54.
    Onishi T, Ohishi Y, Iizuka N, et al. Clinical characteristics of 7 renal cell carcinoma patients developing a solitary pancreatic metastasis after nephrectomy. Nippon Hinyokika Gakkai Zasshi 1995;86:1538–42PubMedGoogle Scholar
  55. 55.
    Orita M, Morita N, Hiraoka H, Noshima S, Takaimashi T, Esato K. A case of resected pancreatic metastasis from renal cell carcinoma 14 years after radical nephrectomy. J Jpn Panc Soc 1995;10:63–8.Google Scholar
  56. 56.
    Takashi M, Takagi Y, Sakata T, Shimoji T, Miyake K. Surgical treatment of renal cell carcinoma metastases: prognostic significance. Int Urol Nephrol 1995;27:1–8PubMedGoogle Scholar
  57. 57.
    Osaka Y, Kato H, Nakamura F, et al. Solitary pancreatic metastasis from renal cell carcinoma. Jpn J Gastroenterol Surg 1994;27:130–4Google Scholar
  58. 58.
    Zugel N, Leipprand F, Weckermann D, Witte J. Solitäre Pankreaskopfmetastase bei hypernephroidem Carcinom. Fortschr Med 1994;112:388–90PubMedGoogle Scholar
  59. 59.
    Aikou S, Tokura Y, Yamafuji K, et al. A resected case of pancreatic metastasis from renal cell carcinoma presenting with acute duodenal bleeding. J Jpn Soc Clin Surg 1993;54:2666–72Google Scholar
  60. 60.
    Calmes J, Meyer A. Pancreatic hypernephroma manifested by a duodenal hemorrhage. Rev Med Suisse Romande 1993;113:629–31PubMedGoogle Scholar
  61. 61.
    Ishikawa T, Horimi T, Majima K. A resected case of pancreatic tumor metastasized from renal cell carcinoma. A review of 11 cases in the Japanese and 13 cases in the foreign literature. J Jpn Soc Clin Surg 1993;51:1642–7Google Scholar
  62. 62.
    Kawaguchi T, Tsunoda T, Tanaka Y, et al. A case of resection of a solitary pancreatic metastasis of renal cell carcinoma occurring 5 years after nephrectomy. J Jpn Panc Soc 1993;8:189–95Google Scholar
  63. 63.
    Marcote-VE, Arlandis F, Baltasar A, Martinez C, Vierna G. Synchronous pancreatic metastasis of renal carcinoma. Rev Esp Enferm Dig 1993;83:471–3Google Scholar
  64. 64.
    Motoyama S, Terashima H, Matsuoka T, Saito M, Abo S. A case of renal cell carcinoma metastasizing to pancreas and skin 19 years after nephrectomy. Jpn J Gastroenterol Surg 1993;26:2859–63Google Scholar
  65. 65.
    Nan Y, Kuno N, Kurimoto K, Nakamura T, Kobayashi S. A resected case of pancreatic tumor metastasized from renal cell carcinoma diagnosed by endoscopic biopsy through the main pancreatic duct. Gastroenterol Endosc 1993;35:1380–5Google Scholar
  66. 66.
    Oda K, Itoh J, Hachisuka K, et al. Value of computer image analysis in improving ERCP images in metastatic tumor of the pancreas. AJR Am J Roentgenol 1993;161:885–6PubMedGoogle Scholar
  67. 67.
    Reale D, Squillaci S, Guarino M, et al. Late pancreatic metastasis of renal carcinoma. Description of 2 cases and review of literature. Minerva Urol Nefrol 1993;45:183–6PubMedGoogle Scholar
  68. 68.
    Sauvanet A, Barthes T, Levy P, Flejou JF. Late pancreatic metastasis from renal cell carcinoma. Pancreas 1993;8:742–6PubMedGoogle Scholar
  69. 69.
    Takeuchi H, Konaga E, Harano M, et al. Solitary pancreatic metastasis from renal cell carcinoma. Acta Med Okayama 1993;47:63–6PubMedGoogle Scholar
  70. 70.
    Vergara V, Marucci M, Marcarino C, Brunello F, Capussotti L. Metastatic involvement of the pancreas from renal cell carcinoma treated by surgery. Ital J Gastroenterol 1993;25:388–90PubMedGoogle Scholar
  71. 71.
    Yanagisawa T, Nakayama K, Kashiwagi M, et al. Three cases of resectable pancreatic metastases from renal cell carcinoma. Geka Shinryo 1993;35:651–5Google Scholar
  72. 72.
    Adachi K, Murabayashi K, Hayashi J, et al. A case of metastatic thyroid and pancreatic cancer from renal cell carcinoma. Tan to Sui 1992;13:791–6.Google Scholar
  73. 73.
    Fujii M, Kogawa T, Matsuyama K, et al. A case of metastatic renal cell carcinoma to pancreas ten years after nephrectomy. J Kyoto Pref Univ Med 1992;101:589–96Google Scholar
  74. 74.
    Melo CR, Melo I, Monteiro A, de Mello E. Pancreatic metastasis from renal cell carcinoma. Arq Gastroenterol 1992;29:110–2PubMedGoogle Scholar
  75. 75.
    Nakagawa K, Tsuchiya T, Momono S, Sasaki Y, Sato T. A case of pancreatic metastasis of renal cell carcinoma. Jpn J Gastroenterol Surg 1992;25:2200–4Google Scholar
  76. 76.
    Rypens F, Van Gansbeke V, Lambilliotte J, Regemorter V, Verhest A, Struyven J. Pancreatic metastasis from renal cell carcinoma. Br J Radiol 1992;65:547–8PubMedGoogle Scholar
  77. 77.
    Stankard C, Karl R. The treatment of isolated pancreatic metastases from renal cell carcinoma: a surgical review. Am J Gastroenterol 1992;87:1658–60PubMedGoogle Scholar
  78. 78.
    Furukawa T, Hattori R, Ohtake H, et al. A resectable case of pancreatic head metastasis from renal cell carcinoma. Hinyouki Geka 1991;4:111–4Google Scholar
  79. 79.
    Kubo K, Morita J, Mizoe J, Ogawa H, Irie G. Renal cell carcinoma metastatic to the pancreas 8 years following nephrectomy. Jpn J Clin Radiol 1991;36:509–12Google Scholar
  80. 80.
    Nishida O, Matsunaga Y, Dekigai H, Um S, Hsieh C, Kimura F. Three elderly cases of renal cell carcinoma with pancreatic metastasis. Nippon Ronen Igakkai Zasshi 1991;28:392–6PubMedGoogle Scholar
  81. 81.
    Oka H, Hatayama T, Taki Y, Ueyama H, Hida S, Noguchi M. A resected case of renal cell carcinoma with metastasis to pancreas. Hinyokika Kiyo 1991;37:1531–4PubMedGoogle Scholar
  82. 82.
    Tabata T, Kuroda Y, Nishimatsu S, Satoh Y. A resected case of pancreatic tumor metastasized from renal cell carcinoma. J Jpn Panc Soc 1991;6:245–50Google Scholar
  83. 83.
    Yamamoto S, Tobinaga K, Taketomi K, Kimino K, Ashizuka S, Kishikawa M. Pancreatic metastasis of renal cell carcinoma occurring 17 years after nephrectomy. J Jpn Soc Clin Surg 1991;52:3006–11Google Scholar
  84. 84.
    Gohji K, Matsumoto O, Kamidono S. Solitary pancreatic metastasis from renal cell carcinoma. Hinyokika Kiyo 1990;36:677–81PubMedGoogle Scholar
  85. 85.
    Terashima M, Abe H, Suga K, et al. Two cases of renal cell carcinoma metastasized to the pancreas and to the gallbladder. Jpn J Gastroenterol Surg 1990;23:1952–6Google Scholar
  86. 86.
    Guyenne C, Rat P, Haas O, Baudet JG, Favre JP. Triple metastase pancreatique d’un cancer du rein traitee par duodenopancreatectomie subtotale. Presse Med 1989;18:231PubMedGoogle Scholar
  87. 87.
    Iwanami M, Nakayoshi A, Yagi H, et al. A resected case of the asymptomatic pancreatic metastasis in the body and tail of the pancreas from renal cell carcinoma. J Jpn Panc Soc 1989;4:100–6Google Scholar
  88. 88.
    Roland C, van Heerden J. Nonpancreatic primary tumors with metastasis to the pancreas. Surg Gynecol Obstet 1989;168:345–7PubMedGoogle Scholar
  89. 89.
    Simpson NS, Mulholland C, Lioe T, Spence R. Late solitary metastatic renal carcinoma in the pancreas. Ulster Med J 1989;58:198–9PubMedGoogle Scholar
  90. 90.
    Strijk SP. Pancreatic metastases of renal cell carcinoma: report of two cases. Gastrointest Radiol 1989;14:123–6PubMedCrossRefGoogle Scholar
  91. 91.
    Temellini F, Bavosi M, Lamarra M, Quagliarini P, Giuliani F. Pancreatic metastasis 25 years after nephrectomy for renal cancer. Tumori 1989;75:503–4PubMedGoogle Scholar
  92. 92.
    Amamiya H, Iizumi T, Yazaki T, et al. A solitary pancreatic metastasis from renal cell carcinoma. Hinyouki Geka 1988;2:167–70Google Scholar
  93. 93.
    Carini M, Selli C, Barbanti G, Bianchi S, Muraro G. Pancreatic late recurrence of bilateral renal cell carcinoma after conservative surgery. Eur Urol 1988;14:258–60PubMedGoogle Scholar
  94. 94.
    Hirano M, Douden K, Bantou H, et al. Solitary pancreatic metastasis occurring 10 years after nephrectomy for carcinoma of the kidney. Tan to Sui 1988;9:233–7Google Scholar
  95. 95.
    Sharma SK, Kumar A, Madhusoodnan P, Banerjee C, Suri S, Dhar M. Solitary pancreatic metastasis from renal cell carcinoma. A rare metastatic site. Indian J Cancer 1988;25:29–32PubMedGoogle Scholar
  96. 96.
    Audisio R, La Monica G. Solitary pancreatic metastasis occurring 20 years after nephrectomy for carcinoma of the kidney. Tumori 1985;71:197–200PubMedGoogle Scholar
  97. 97.
    Kishimoto H, Niumra Y, Okamoto K, Tsuchie K. A case of resected renal cell carcinoma with massive pancreatic metastasis. Gan No Rinsho 1985;31:91–6PubMedGoogle Scholar
  98. 98.
    Py J, Arnoud J, Cinqualbre J, Adloff M, Bollack C. Les metastases pancreatiques des nephro-epitheliomes. Acta Chir Belg 1984;84:117–21PubMedGoogle Scholar
  99. 99.
    Skaarup P, Jorgensen T, Larsen S. Asynchronous metastasizing renal cell carcinoma associated with progressive immune complex glomerulonephritis and proteinuria. Scand J Urol Nephrol 1984;18:351–6PubMedCrossRefGoogle Scholar
  100. 100.
    Weerdenburg JP, Jurgens P. Late metastases of a hypernephroma to the thyroid and pancreas. Diagn Imaging Clin Med 1984;53:269–72PubMedGoogle Scholar
  101. 101.
    Yazaki T, Ishikawa S, Ogawa Y, Takahashi S, Nemoto S, Rinsho K. Silent pancreatic metastasis from renal cell carcinoma. Acta Urol Jpn 1981;27:1517–22Google Scholar
  102. 102.
    Saxon A, Gottesman J, Doolas A. Bilateral hypernephroma with solitary pancreatic metastasis. J Surg Oncol 1980;13:317–22PubMedGoogle Scholar
  103. 103.
    Hermanutz KD, Sonnenberg GE. Late metastasis of a hypernephroid kidney carcinoma to the pancreas with tumor invasion to the duodenum. Fortschr Rontgenstr 1977;127:595–7CrossRefGoogle Scholar
  104. 104.
    Gillet M, Camelit G, Runser G, Clement D. Duodenopancreatic metastasis of kidney cancer revealed by digestive hemorrhage treated by cephalic duodeno-pancreatectomy. Chirurgie 1974;100:226–30PubMedGoogle Scholar
  105. 105.
    Guttman F, Ross M, Lachance C. Pancreatic metastasis of renal cell carcinoma treated by total pancreatectomy. Arch Surg 1972;105:782–4PubMedGoogle Scholar
  106. 106.
    Marquand J, Giraud B, Maliakas S. Pancreatic metastasis revealing a kidney neoplasm. J Urol Nephrol 1971;77:595–601Google Scholar
  107. 107.
    Franciosi RA, Russo J. Renal cell carcinoma metastatic to the pancreas thirteen years following nephrectomy. Mil Med 1969;134:200–3PubMedGoogle Scholar
  108. 108.
    Lawson L, Holt L, Rooke H. Recurrent duodenal haemorrhage from renal carcinoma. Br J Urol 1966;38:133–7PubMedCrossRefGoogle Scholar
  109. 109.
    Jenssen E. A metastatic hypernephroma to the pancreas. Acta Chir Scand 1952;104:177–80PubMedGoogle Scholar
  110. 110.
    Tuech J, Pessaux P, Chautard D, et al. Results of duodenopancreatectomy for solitary pancreatic metastasis from renal cell carcinoma. J Hepatobiliary Pancreat Surg 1999;6:396–8PubMedCrossRefGoogle Scholar
  111. 111.
    Bechade D, Palazzo L, Fabre M, Sigsyres J. EUS-guided FNA of pancreatic metastasis from renal cell carcinoma. Gastrointest Endosc 2003;58:784–8PubMedCrossRefGoogle Scholar
  112. 112.
    Klein K, Stephens D, Welch T. CT characteristics of metastatic disease of the pancreas. Radiographics 1998;18:369–78PubMedGoogle Scholar
  113. 113.
    Wittekind C, Klimpfinger M, Sobin LH. TNM Atlas. 5th ed. Heidelberg: Springer, 2005Google Scholar
  114. 114.
    Allen-Mersh T. Significance of the site of origin of pancreatic exocrine adenocarcinoma. J Clin Pathol 1982;35:544–6PubMedGoogle Scholar
  115. 115.
    Bassi C, Butturini G, Falconi M, et al. High recurrence rate after atypical resection for pancreatic metastases from renal cell carcinoma. Br J Surg 2003;90:555–9PubMedCrossRefGoogle Scholar
  116. 116.
    Nakamura E, Shimizu M, Itoh T, Manabe T. Secondary tumors of the pancreas: clinicopathological study of 103 autopsy cases of Japanese patients. Pathol Int 2001;51:686–90PubMedCrossRefGoogle Scholar
  117. 117.
    Whittington R, Moylan D, Doblebower R, Kramer S. Pancreatic tumours in patients with previous malignancy. Clin Radiol 1982;33:297–9PubMedCrossRefGoogle Scholar
  118. 118.
    Wernecke K, Peters P, Galanski M. Pancreatic metastases: US evaluation. Radiology 1986;160:399–402PubMedGoogle Scholar
  119. 119.
    Kelekis N, Semelka R, Siegelman E. MRI of pancreatic metastases from renal cancer. J Comput Assist Tomogr 1996;20:249–253PubMedCrossRefGoogle Scholar
  120. 120.
    Biset J, Laurent F, de Verbizier G, Houang B, Constantes G, Drouillard J. Ultrasound and computed tomographic findings in pancreatic metastases. Eur J Radiol 1991;12:41–4PubMedCrossRefGoogle Scholar
  121. 121.
    Fritscher-Ravens A, Sriram P, Krause C, et al. Detection of pancreatic metastases by EUS-guided fine-needle aspiration. Gastrointest Endosc 2001;53:65–70PubMedGoogle Scholar
  122. 122.
    Wood T, DiFronzo A, Rose M, et al. Does complete resection of melanoma metastatic to solid intraabdominal organs improve survival? Ann Surg Oncol 2001;8:658–62PubMedGoogle Scholar
  123. 123.
    Janes R, Niederhuber J, Chmiel J, et al. National patterns of care for pancreatic cancer. Results of a survey by the commission on cancer. Ann Surg 1996;223:261–72PubMedCrossRefGoogle Scholar
  124. 124.
    Shoup M, Colon K, Klimstra D, Brennan M. Is extended resection for adenocarcinoma of the body or tail of the pancreas justified? J Gastrointest Surg 2003;7:946–52PubMedGoogle Scholar
  125. 125.
    Wente M, Kleeff J, Esposito I, et al. Renal cancer cell metastases in to the pancreas. A single center experience and overview of the literature. Pancreas 2005;30:218–22PubMedCrossRefGoogle Scholar
  126. 126.
    Bichsel V, Liotta L, Petricoin E. Cancer proteomics: from biomarker discovery to signal pathway profiling. Cancer J 2001;7:69–78PubMedGoogle Scholar
  127. 127.
    Liotta LA, Kohn E. The microenvironment of tumour-host interface. Nature 2001;411:375–9PubMedCrossRefGoogle Scholar
  128. 128.
    Ward Y, Wang W, Woodhouse E, Linnoila I, Liotta L, Kelly K. Signal pathways which promote invasion and metastasis: critical and distinct contributions of extracellular signal-regulated kinase and ral-specific guanine exchange factor pathways. Mol Cell Biol 2001;21:5958–69PubMedCrossRefGoogle Scholar

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© The Society of Surgical Oncology, Inc. 2006

Authors and Affiliations

  • Franz Sellner
    • 1
  • Natascha Tykalsky
    • 1
  • Maria De Santis
    • 2
  • Jörg Pont
    • 2
  • M. Klimpfinger
    • 3
  1. 1.Surgical DepartmentKaiser Franz Josef HospitalAustria
  2. 2.Department of Medical OncologyKaiser Franz Josef HospitalAustria
  3. 3.Institute of PathologyKaiser Franz Josef HospitalAustria

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