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Annals of Surgical Oncology

, Volume 11, Issue 3, pp 274–280 | Cite as

Results of R0 Resection for Colorectal Liver Metastases Associated With Extrahepatic Disease

  • Dominique Elias
  • Lucas Sideris
  • Marc Pocard
  • Jean-Francois Ouellet
  • Valérie Boige
  • Philippe Lasser
  • Jean-Pierre Pignon
  • Michel Ducreux
Original Articles

Abstract

Background: Extrahepatic malignant disease has always been considered an absolute contraindication to hepatectomy for colorectal liver metastases. This study reports the long-term outcome and prognostic factors of patients undergoing extrahepatic disease resection simultaneously with hepatectomy for liver metastases.

Methods: From January 1987 to January 2001, 75 patients underwent a complete R0 resection of extrahepatic disease simultaneously with hepatectomy for colorectal liver metastases. They were inscribed in a registry and then prospectively followed up. They represented 25% of the 294 patients who underwent an R0 hepatectomy for colorectal liver metastases during the same period.

Results: The mortality rate was 2.7%, and morbidity was 25%. After a median follow-up of 4.9 years (range, 1.7–13.4 years), the overall 3- and 5-year survival rates were 45% and 28%, respectively. By using a Cox model, there was a significant difference in survival between patients with single versus multiple sites of extrahepatic disease. Also, the presence of more than five liver metastases was a significant parameter.

Conclusions: Extrahepatic disease in colorectal cancer patients with liver metastases should no longer be considered as a contraindication to hepatectomy. However, this intended R0 resection cannot be performed in 50% of laparotomized patients, and negative prognostic factors for surgery include the presence of multiple extrahepatic disease sites or more than five liver metastases.

Key Words

Liver metastases Colorectal Extrahepatic disease Surgery 

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Copyright information

© The Society of Surgical Oncology, Inc. 2004

Authors and Affiliations

  • Dominique Elias
    • 1
    • 4
  • Lucas Sideris
    • 1
  • Marc Pocard
    • 1
  • Jean-Francois Ouellet
    • 1
  • Valérie Boige
    • 2
  • Philippe Lasser
    • 1
  • Jean-Pierre Pignon
    • 3
  • Michel Ducreux
    • 2
  1. 1.Departments of Surgical OncologyGustave Roussy InstituteVillejuifFrance
  2. 2.Departments of Medical OncologyGustave Roussy InstituteVillejuifFrance
  3. 3.Departments of Biostatistics and EpidemiologyGustave Roussy InstituteVillejuifFrance
  4. 4.Department of Surgery, Division of Surgical OncologyGustave Roussy InstituteVillejuif CEDEXFrance

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