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Annals of Surgical Oncology

, Volume 26, Issue 11, pp 3602–3610 | Cite as

Characteristics and Survival of Gastric Cancer Patients with Pathologic Complete Response to Preoperative Therapy

  • Alexander P. Stark
  • Naruhiko IkomaEmail author
  • Yi-Ju Chiang
  • Jeannelyn S. Estrella
  • Prajnan Das
  • Bruce D. Minsky
  • Mariela M. Blum
  • Jaffer A. Ajani
  • Paul Mansfield
  • Brian D. Badgwell
Gastrointestinal Oncology
  • 128 Downloads

Abstract

Background

Pathologic complete response of a primary tumor (ypT0) after preoperative therapy is associated with improved overall survival (OS). However, whether other variables are associated with outcome for gastric cancer patients with ypT0 status is unknown.

Methods

This study reviewed an institutional database of patients who underwent resection of gastric or gastroesophageal adenocarcinoma after preoperative therapy and identified patients with ypT0 status. Cox regression models were used to identify clinicopathologic predictors of OS.

Results

Of 77 patients with ypT0 status identified in this study, 36 (47%) had gastroesophageal junction tumors. At presentation, 62 patients (81%) had clinical T3 disease, and 7 (9%) had clinical T4 disease. The clinical nodal status was positive (cN+) for 45 patients (58%). Preoperative chemoradiation was administered to 75 patients (97%). The median follow-up duration was 3.54 years. The median OS was 10 years, and the 5-year OS rate was 61%. Univariable analysis identified age of 65 years or older at the time of diagnosis, histologic grade, and ypN status as significant predictors of OS. Multivariable analysis confirmed age of 65 years or older [hazard ratio (HR), 4.26; p < 0.001] and persistent nodal disease (ypN+ status; HR, 5.12; p < 0.001) to be independently associated with OS. Clinical stage was not associated with survival. In the subset of ypT0N0 patients, no clinicopathologic feature was predictive of survival.

Conclusion

For gastric or gastroesophageal adenocarcinoma patients with ypT0 status after preoperative therapy, ypN+ status substantially reduced survival. Pretreatment clinical stage had no impact on OS for patients with a pathologic complete response.

Notes

Acknowledgment

This study was supported in part by the NIH/NCI under Award Number P30CA016672 and used the Clinical Trials Support Resource. Prajnan Das has received consulting fees from Adlai Nortye for serving on an Independent Advisory Panel.

Author contributions

AS (design, analysis, drafting, editing), NI (design, acquisition, analysis, drafting, editing, final approval), YC (analysis, interpretation, editing, final approval), JE (acquisition, editing, final approval), PD (acquisition, editing, final approval), BM (acquisition, editing, final approval), MB (acquisition, editing, final approval), JA (acquisition, editing, final approval), PM (acquisition, editing, final approval), BB (design, acquisition, analysis, drafting, editing, final approval).

Disclosure

There are no conflicts of interest.

Supplementary material

10434_2019_7638_MOESM1_ESM.docx (14 kb)
Supplementary material 1 (DOCX 14 kb)

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Copyright information

© Society of Surgical Oncology 2019

Authors and Affiliations

  • Alexander P. Stark
    • 1
  • Naruhiko Ikoma
    • 1
    Email author
  • Yi-Ju Chiang
    • 1
  • Jeannelyn S. Estrella
    • 2
  • Prajnan Das
    • 3
  • Bruce D. Minsky
    • 3
  • Mariela M. Blum
    • 4
  • Jaffer A. Ajani
    • 4
  • Paul Mansfield
    • 1
  • Brian D. Badgwell
    • 1
  1. 1.Department of Surgical OncologyThe University of Texas MD Anderson Cancer CenterHoustonUSA
  2. 2.Department of PathologyThe University of Texas MD Anderson Cancer CenterHoustonUSA
  3. 3.Department of Radiation OncologyThe University of Texas MD Anderson Cancer CenterHoustonUSA
  4. 4.Department of Gastrointestinal Medical OncologyThe University of Texas MD Anderson Cancer CenterHoustonUSA

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