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Annals of Surgical Oncology

, Volume 26, Issue 10, pp 3133–3140 | Cite as

A Comparison of Patient-Reported Outcomes After Breast-Conserving Surgery and Mastectomy with Implant Breast Reconstruction

  • Meghan R. Flanagan
  • Emily C. Zabor
  • Anya Romanoff
  • Sarah Fuzesi
  • Michelle Stempel
  • Babak J. Mehrara
  • Monica Morrow
  • Andrea L. Pusic
  • Mary L. GemignaniEmail author
Breast Oncology

Abstract

Background

Many factors influence decisions regarding choice of breast-conserving surgery (BCS) versus mastectomy with reconstruction for early invasive breast cancer. The purpose of this study was to compare patient satisfaction following BCS and mastectomy with implant reconstruction (M-iR) utilizing the BREAST-Q patient-reported outcome measure.

Methods

Women with stage I or II breast cancer undergoing BCS or M-iR who completed a BREAST-Q from 2010 to 2016 were identified by retrospective review of a prospective database. Baseline characteristics were compared, and linear mixed models were used to analyze associations with BREAST-Q scores over time.

Results

Our study group was composed of 3233 women; 2026 (63%) had BCS, 123 (3.8%) had nipple-sparing mastectomy, and 1084 (34%) had skin-sparing or total mastectomy. Median time from surgery to BREAST-Q was 205 days for BCS and 639 days for M-iR (p < 0.001). Regardless of type of surgery, breast satisfaction scores decreased significantly over time (p < 0.001), whereas psychosocial (p = 0.001) and sexual (p = 0.004) well-being scores increased significantly over time. BCS was associated with significantly higher scores over time compared with M-iR across all subscales (all p < 0.001). Radiation was significantly associated with decreased scores over time across all subscales (all p < 0.05).

Conclusions

Breast satisfaction and quality-of-life scores were higher for BCS compared with M-iR in early-stage invasive breast cancer. These findings may help in counseling women who have a choice for surgical treatment. Breast satisfaction scores decreased over time in all women, highlighting the need for further evaluation with longer follow-up.

Notes

Disclosures

The preparation of this manuscript was funded in part by NIH/NCI Cancer Center Support Grant No. P30 CA008748 to Memorial Sloan Kettering Cancer Center, and this study was presented in podium format at the 20th Annual Meeting of the American Society of Breast Surgeons, April 30–May 5, 2019, Dallas, TX. Dr. Babak Mehrara has received salary support for a research project sponsored by aTyr Corporation, and Dr. Monica Morrow has received speaking honoraria from Genomic Health and Roche. Dr. Andrea Pusic is a co-developer of the BREAST-Q and receives royalties when the questionnaire is used in for-profit industry-sponsored clinical trials.

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Copyright information

© Society of Surgical Oncology 2019

Authors and Affiliations

  • Meghan R. Flanagan
    • 1
  • Emily C. Zabor
    • 2
  • Anya Romanoff
    • 1
  • Sarah Fuzesi
    • 1
  • Michelle Stempel
    • 1
  • Babak J. Mehrara
    • 3
  • Monica Morrow
    • 1
  • Andrea L. Pusic
    • 4
  • Mary L. Gemignani
    • 1
    Email author
  1. 1.Breast Service, Department of SurgeryMemorial Sloan Kettering Cancer CenterNew YorkUSA
  2. 2.Biostatistics Service, Department of Epidemiology and BiostatisticsMemorial Sloan Kettering Cancer CenterNew YorkUSA
  3. 3.Plastic and Reconstructive Surgical Service, Department of SurgeryMemorial Sloan Kettering Cancer CenterNew YorkUSA
  4. 4.Plastic and Reconstructive Surgery DivisionBrigham and Women’s HospitalBostonUSA

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