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Annals of Surgical Oncology

, Volume 26, Issue 11, pp 3561–3567 | Cite as

Influence of Molecular Status on Recurrence Site in Patients Treated for a Stage III Colon Cancer: a Post Hoc Analysis of the PETACC-8 Trial

  • M. BruzziEmail author
  • E. Auclin
  • R. Lo Dico
  • T. Voron
  • M. Karoui
  • E. Espin
  • F. Cianchi
  • J. Weitz
  • A. Buggenhout
  • R. Malafosse
  • F. Denimal
  • K. Le Malicot
  • D. Vernerey
  • R. Douard
  • J. F. Emile
  • C. Lepage
  • P. Laurent-Puig
  • J. Taieb
Colorectal Cancer
  • 129 Downloads

Abstract

Background

Recurrence patterns in stage III colon cancer (CC) patients according to molecular markers remain unclear. The objective of the study was to assess recurrence patterns according to microsatellite instability (MSI), RAS and BRAFV600E status in stage III CC patients.

Methods

All stage III CC patients from the PETACC-8 randomized trial tested for MSI, RAS and BRAFV600E status were included. The site and characteristics of recurrence were analyzed according to molecular status. Survival after recurrence (SAR) was analyzed.

Results

A total of 1650 patients were included. Recurrence occurred in 434 patients (26.3%). Microsatellite stable (MSS) patients had a significantly higher recurrence rate (27.2% vs. 18.7%, P = 0.02) with a trend to more pulmonary recurrence (28.8% vs. 12.9%, P = 0.06) when compared to MSI patients. MSI patients experienced more regional lymph nodes compared to MSS (12.9% vs. 4%, P = 0.046). In the MSS population, the recurrence rate was significantly higher in RAS (32.2%) or BRAF (32.3%) patients when compared to double wild-type patients (19.9%) (p < 0.001); no preferential site of recurrence was observed according to RAS and BRAFV600E mutations. Finally, decreased SAR was observed in the case of peritoneal recurrence or more than two recurrence sites.

Conclusions

Microsatellite, RAS and BRAFV600E status influences recurrence rates in stage III CC patients. However, only microsatellite status seems to be associated with specific recurrence patterns. More than two recurrence sites and recurrence in the peritoneum were associated with poorer SAR.

Notes

Supplementary material

10434_2019_7513_MOESM1_ESM.docx (15 kb)
Supplementary material 1 (DOCX 14 kb)
10434_2019_7513_MOESM2_ESM.docx (15 kb)
Supplementary material 2 (DOCX 14 kb)

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Copyright information

© Society of Surgical Oncology 2019

Authors and Affiliations

  • M. Bruzzi
    • 1
    Email author
  • E. Auclin
    • 2
    • 13
  • R. Lo Dico
    • 3
  • T. Voron
    • 4
  • M. Karoui
    • 5
  • E. Espin
    • 6
  • F. Cianchi
    • 7
  • J. Weitz
    • 8
  • A. Buggenhout
    • 9
  • R. Malafosse
    • 10
  • F. Denimal
    • 11
  • K. Le Malicot
    • 12
  • D. Vernerey
    • 13
  • R. Douard
    • 1
  • J. F. Emile
    • 14
  • C. Lepage
    • 15
  • P. Laurent-Puig
    • 16
  • J. Taieb
    • 2
  1. 1.Department of General and Digestive Surgery, Georges Pompidou European HospitalAP-HPParisFrance
  2. 2.Department of Digestive Oncology, Georges Pompidou European HospitalAP-HPParisFrance
  3. 3.Department of Digestive and Oncological Surgery, Lariboisière HospitalAP-HPParisFrance
  4. 4.Department of Digestive and General Surgery, Saint Antoine HospitalAP-HP, Sorbonne UniversitéParisFrance
  5. 5.Department of Digestive and Hepato-Pancreato-Biliary Surgery, Pitié-Salpêtrière University HospitalAP-HP, Paris VI University Institute of CancerologyParisFrance
  6. 6.Department of General Surgery, Hospital Valle de HebronUniversitat Autonoma de BarcelonaBarcelonaSpain
  7. 7.Department of Experimental and Clinical MedicineUniversity of FlorenceFlorenceItaly
  8. 8.Department of Visceral, Thoracic and Vascular SurgeryUniversity Hospital Carl Gustav Carus of the Technical University DresdenDresdenGermany
  9. 9.Department of Surgical Gastroenterology, Erasme HospitalUniversité Libre de BruxellesBrusselsBelgium
  10. 10.Department of Digestive Surgery, Ambroise-Paré HospitalAP-HPBoulogneFrance
  11. 11.Department of Digestive SurgeryCentre Hospitalier Départemental VendéeLa Roche Sur YonFrance
  12. 12.Statistical Department, Fédération Francophone de Cancérologie Digestive, EPICAD, INSERM LNC-UMR 1231University of Burgundy and Franche Comté, DijonDijonFrance
  13. 13.Methodological and Quality of Life in Oncology Unit, EA 3181University Hospital of BesançonBesançonFrance
  14. 14.Pathology Department, Ambroise-Paré HospitalAP-HPBoulogneFrance
  15. 15.Hepato-Gastroenterology Department, Dijon University Hospital and EPICAD INSERM LNC-UMR 1231University of Burgundy and Franche ComtéDijonFrance
  16. 16.Department of Biology, European Georges Pompidou HospitalAP-HP, INSERM-UMR-S1147ParisFrance

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