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Obstruction-Free Survival Following Operative Intervention for Malignant Bowel Obstruction in Appendiceal Cancer

  • Joel M. BaumgartnerEmail author
  • Rebecca Marmor
  • Athena Hsu
  • Jula Veerapong
  • Kaitlyn J. Kelly
  • Andrew M. Lowy
Gastrointestinal Oncology
  • 9 Downloads

Abstract

Background

Patients with peritoneal metastases from appendiceal cancer are at high risk of malignant bowel obstruction (MBO), which is associated with significant morbidity and mortality. There are no definitive treatment guidelines regarding operative intervention for MBO. We sought to evaluate the efficacy and safety of operative intervention in this population.

Methods

We identified patients with peritoneal metastases from appendiceal cancer who underwent surgery for MBO at our institution between 2011 and 2018. Baseline characteristics, postoperative complications, and follow-up data were collected. The primary endpoint was obstruction-free survival (OFS). Other endpoints were postoperative recovery of bowel function, 60-day Clavien–Dindo (CD) morbidity, and overall survival (OS).

Results

Twenty-six patients underwent operative treatment for MBO, of whom 14 had high-grade (HG) histology and 12 had low-grade (LG) histology. Seven (25.9%) patients had severe (CD grade 3 or higher) 60-day complications, including one (3.8%) postoperative death. All remaining patients had return of bowel function and resumed oral intake during hospitalization. Six (23.1%) patients had repeat admissions for MBO after surgery. Median OFS was 17.0 months (95% confidence interval [CI] 2.3–31.8), and median OS was 18.5 months (95% CI 3.6–33.3) following surgery.

Conclusion

In this carefully selected group of patients with peritoneal metastases from appendiceal cancer, surgery for MBO provided durable palliation with acceptable morbidity.

Notes

Acknowledgment

This study was supported by a University of California San Diego Clinical and Translational Research Institute Grant (UL1TR001442).

Disclosures

Joel M. Baumgartner, Rebecca Marmor, Athena Hsu, Jula Veerapong, Kaitlyn J. Kelly, and Andrew M. Lowy have no disclosures or relevant conflicts of interest to declare.

References

  1. 1.
    Chakraborty A, Selby D, Gardiner K, Myers J, Moravan V, Wright F. Malignant bowel obstruction: natural history of a heterogeneous patient population followed prospectively over two years. J Pain Symptom Manag. 2011;41(2):412–420.CrossRefGoogle Scholar
  2. 2.
    Feuer DJ, Broadley KE, Shepherd JH, Barton DP. Surgery for the resolution of symptoms in malignant bowel obstruction in advanced gynaecological and gastrointestinal cancer. Cochrane Database Syst Rev. 2000;(4):CD002764.Google Scholar
  3. 3.
    Francescutti V, Miller A, Satchidanand Y, Alvarez-Perez A, Dunn KB. Management of bowel obstruction in patients with stage IV cancer: predictors of outcome after surgery. Ann Surg Oncol. 2013;20(3):707–714.CrossRefGoogle Scholar
  4. 4.
    Wong TH, Tan YM. Surgery for the palliation of intestinal obstruction in advanced abdominal malignancy. Singap Med J. 2009;50(12):1139–1144.Google Scholar
  5. 5.
    Henry JC, Pouly S, Sullivan R, et al. A scoring system for the prognosis and treatment of malignant bowel obstruction. Surgery. 2012;152(4):747–756; discussion 756–747.Google Scholar
  6. 6.
    Hwang M, Pirrello R, Pu M, Messer K, Roeland E. Octreotide prescribing patterns in the palliation of symptomatic inoperable malignant bowel obstruction patients at a single US academic hospital. Support Care Cancer. 2013;21(10):2817–2824.CrossRefGoogle Scholar
  7. 7.
    Soriano A, Davis MP. Malignant bowel obstruction: individualized treatment near the end of life. Cleve Clin J Med. 2011;78(3):197–206.CrossRefGoogle Scholar
  8. 8.
    Dolan EA. Malignant bowel obstruction: a review of current treatment strategies. Am J Hosp Palliat Care. 2011;28(8):576–582.CrossRefGoogle Scholar
  9. 9.
    Roeland EJ. Managing malignant bowel obstruction: moving beyond drip and suck. J Oncol Pract. 2017;13(7):437–438.CrossRefGoogle Scholar
  10. 10.
    Pujara D, Chiang YJ, Cormier JN, Bruera E, Badgwell B. Selective approach for patients with advanced malignancy and gastrointestinal obstruction. J Am Coll Surg. 2017;225(1):53–59.CrossRefGoogle Scholar
  11. 11.
    Paul Olson TJ, Pinkerton C, Brasel KJ, Schwarze ML. Palliative surgery for malignant bowel obstruction from carcinomatosis: a systematic review. JAMA Surg. 2014;149(4):383–392.CrossRefGoogle Scholar
  12. 12.
    White SI, Abdool SI, Frenkiel B, Braun WV. Management of malignant left-sided large bowel obstruction: a comparison between colonic stents and surgery. ANZ J Surg. 2011;81(4):257–260.CrossRefGoogle Scholar
  13. 13.
    Santangelo ML, Grifasi C, Criscitiello C, et al. Bowel obstruction and peritoneal carcinomatosis in the elderly. A systematic review. Aging Clin Exp Res. 2017;29 Suppl 1:73–78.Google Scholar
  14. 14.
    Shaib WL, Goodman M, Chen Z, et al. Incidence and survival of appendiceal mucinous neoplasms: a SEER analysis. Am J Clin Oncol. 2017;40(6):569–573.CrossRefGoogle Scholar
  15. 15.
    Ihemelandu C, Fernandez S, Sugarbaker PH. A prognostic model for predicting overall survival in patients with peritoneal surface malignancy of an appendiceal origin treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Ann Surg Oncol. 2017;24(8):2266–2272.CrossRefGoogle Scholar
  16. 16.
    World Health Organization Classification of Tumours of the Digestive Tract. Vol 3. 4th ed. Lyon: IARC Press; 2010Google Scholar
  17. 17.
    Carr NJ, Cecil TD, Mohamed F, et al. A consensus for classification and pathologic reporting of pseudomyxoma peritonei and associated appendiceal Neoplasia: the results of the Peritoneal Surface Oncology Group International (PSOGI) modified delphi process. Am J Surg Pathol. 2016;40(1):14–26.CrossRefGoogle Scholar
  18. 18.
    Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205–213.CrossRefGoogle Scholar
  19. 19.
    Folkert IW, Roses RE. Value in palliative cancer surgery: a critical assessment. J Surg Oncol. 2016;114(3):311–315.CrossRefGoogle Scholar
  20. 20.
    Asare EA, Compton CC, Hanna NN, et al. The impact of stage, grade, and mucinous histology on the efficacy of systemic chemotherapy in adenocarcinomas of the appendix: analysis of the national cancer data base. Cancer. 2016;122(2):213–221.CrossRefGoogle Scholar
  21. 21.
    SWOG. SWOG Study S1316. Prospective comparative effectiveness trial for malignant bowel obstruction. 2017. Available at: http://swog.org/Visitors/S1316/.

Copyright information

© Society of Surgical Oncology 2019

Authors and Affiliations

  • Joel M. Baumgartner
    • 1
    Email author
  • Rebecca Marmor
    • 1
  • Athena Hsu
    • 1
  • Jula Veerapong
    • 1
  • Kaitlyn J. Kelly
    • 1
  • Andrew M. Lowy
    • 1
  1. 1.Department of SurgeryUniversity of California, San Diego Moores Cancer CenterLa JollaUSA

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