Reply to Letter to the Editor Regarding “The Importance of Diagnosing Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) Based on the Defined Criteria”
We thank Dr. Rosario for his letter, which stimulates discussion around this important new diagnostic entity. We agree with Dr. Rosario’s point that improvements in methodology would result if there were a secondary review of all pathology specimens in the study;1however, this is both not feasible and also not necessary to demonstrate our main conclusion. The added benefit of our current methodology is that it provides a unique dataset with long-term survival that would otherwise not be possible in most retrospective studies. Given the long-term survival and its importance in studying noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), many of the cell blocks and histology slides would realistically no longer be available. The recommendation against the diagnosis being made on the original pathology report by the American Association of Clinical Endocrinologists (AACE) and the American Head and Neck Society (AHNS), quoted by Dr. Rosario,...
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