Impact of Family History on Prognosis of Patients with Sporadic Colorectal Cancer
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A family history (FH) of colorectal cancer (CRC) increases the risk for development of CRC, but the impact of FH of CRC on survival from sporadic CRC is unclear. This study investigated the prognostic impact of FH of CRC on the recurrence and survival of patients with sporadic CRC.
We reviewed the records of patients with sporadic CRC from two tertiary referral hospitals in Korea who underwent surgical resection between May 2007 and September 2013. The clinicopathologic features and oncologic outcomes of those with and without FHs of CRC were compared.
We examined the records of 2960 eligible patients, 163 (5.5%) of whom had first-degree relatives with CRC. Patients with and without FHs of CRC had similar baseline characteristics. Multivariable analysis indicated that a FH of CRC was not significantly associated with disease-free survival but was significantly associated with better overall survival (OS) [adjusted hazard ratio = 0.539, 95% confidence interval (CI) 0.330–0.881, P = 0.014]. Subgroup analysis indicated that females and rectal cancer patients with FHs of CRC had significantly better prognoses. Microsatellite status did not affect the improved survival rate associated with FH.
This study of patients with sporadic CRC indicated that those who had FHs of CRC had better OS but similar cancer recurrence as those who had no FH of CRC. The effect of FH of CRC on OS was independent of microsatellite status. Further studies are needed to identify underlying mechanisms and determine the optimal clinical management of CRC according to FH.
This study was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (Grant Number NRF-2017R1A2B4012238).
The authors declare no conflicts of interest.
- 3.Boland CR, Goel A. Microsatellite instability in colorectal cancer. Gastroenterology. 2010;138(6):2073–87 e3.Google Scholar
- 16.Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A. American Joint Committee on Cancer Staging Manual. 7th ed. New York: Springer; 2009.Google Scholar
- 17.National Comprehensive Cancer Network. Clinical practice guidelines in oncology—genetic/familial high-risk assessment: Colorectal. Accessed 1 Mar 2018.Google Scholar
- 18.National Comprehensive Cancer Network. Colon cancer clinical practice guidelines in oncology. Available at: http://www.nccn.org/professionals/physician_gls/pdf/colon.pdf. Accessed 1 Mar 2018.
- 19.National Comprehensive Cancer Network. Rectal cancer clinical practice guidelines in oncology. Available at: http://www.nccn.org/professionals/physician_gls/pdf/rectal.pdf. Accessed 1 Mar 2018.
- 25.Schoen RE, Razzak A, Yu KJ, et al. Incidence and Mortality of Colorectal Cancer in Individuals With a Family History of Colorectal Cancer. Gastroenterology. 2015;149(6):1438–45 e1.Google Scholar