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Impact of Family History on Prognosis of Patients with Sporadic Colorectal Cancer

  • Soo Young Lee
  • Duck-Woo KimEmail author
  • Sung Il Kang
  • Myong Hoon Ihn
  • Heung-Kwon Oh
  • Sung-Bum Kang
  • Chang Hyun Kim
  • Hyeong Rok Kim
  • Young Jin Kim
  • Jae Kyun Ju
Colorectal Cancer
  • 31 Downloads

Abstract

Purpose

A family history (FH) of colorectal cancer (CRC) increases the risk for development of CRC, but the impact of FH of CRC on survival from sporadic CRC is unclear. This study investigated the prognostic impact of FH of CRC on the recurrence and survival of patients with sporadic CRC.

Methods

We reviewed the records of patients with sporadic CRC from two tertiary referral hospitals in Korea who underwent surgical resection between May 2007 and September 2013. The clinicopathologic features and oncologic outcomes of those with and without FHs of CRC were compared.

Results

We examined the records of 2960 eligible patients, 163 (5.5%) of whom had first-degree relatives with CRC. Patients with and without FHs of CRC had similar baseline characteristics. Multivariable analysis indicated that a FH of CRC was not significantly associated with disease-free survival but was significantly associated with better overall survival (OS) [adjusted hazard ratio = 0.539, 95% confidence interval (CI) 0.330–0.881, P = 0.014]. Subgroup analysis indicated that females and rectal cancer patients with FHs of CRC had significantly better prognoses. Microsatellite status did not affect the improved survival rate associated with FH.

Conclusions

This study of patients with sporadic CRC indicated that those who had FHs of CRC had better OS but similar cancer recurrence as those who had no FH of CRC. The effect of FH of CRC on OS was independent of microsatellite status. Further studies are needed to identify underlying mechanisms and determine the optimal clinical management of CRC according to FH.

Notes

Funding

This study was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (Grant Number NRF-2017R1A2B4012238).

DISCLOSURE

The authors declare no conflicts of interest.

Supplementary material

10434_2019_7179_MOESM1_ESM.docx (18 kb)
Supplementary material 1 (DOCX 17 kb)
10434_2019_7179_MOESM2_ESM.docx (16 kb)
Supplementary material 2 (DOCX 15 kb)

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Copyright information

© Society of Surgical Oncology 2019

Authors and Affiliations

  • Soo Young Lee
    • 1
  • Duck-Woo Kim
    • 2
    • 3
    Email author
  • Sung Il Kang
    • 2
  • Myong Hoon Ihn
    • 4
  • Heung-Kwon Oh
    • 2
  • Sung-Bum Kang
    • 2
  • Chang Hyun Kim
    • 1
  • Hyeong Rok Kim
    • 1
  • Young Jin Kim
    • 1
  • Jae Kyun Ju
    • 5
  1. 1.Department of SurgeryChonnam National University Hwasun Hospital and Medical SchoolHwasunKorea
  2. 2.Department of SurgerySeoul National University Bundang HospitalSeongnamKorea
  3. 3.Korean Hereditary Tumor RegistrySeoul National University College of MedicineSeoulKorea
  4. 4.Department of SurgerySoonchunhyang University Gumi HospitalGumiKorea
  5. 5.Department of SurgeryChonnam National University Hospital and Medical SchoolGwangjuKorea

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