Annals of Surgical Oncology

, Volume 25, Supplement 3, pp 681–682 | Cite as

ASO Author Reflections: Shifting the Focus of pT1–2pN1 Breast Cancer: Are We Evaluating the Right Endpoint in Tailoring Adjuvant Radiation Therapy Recommendations?

  • Jose G. Bazan
  • Julia R. White
ASO Author Reflections



Jose G. Bazan and Julia R. White have no conflicts of interest to disclose.


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    McGale P, Taylor C, et al. (2014) Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials. Lancet. 383(9935):2127–2135.CrossRefGoogle Scholar
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    McBride A, Allen P, Woodward W, et al. Locoregional recurrence risk for patients with T1,2 breast cancer with 1-3 positive lymph nodes treated with mastectomy and systemic treatment. Int J Radiat Oncol Biol Phys. 2014;89(2):392–398.CrossRefGoogle Scholar
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    Poortmans PM, Collette S, Kirkove C, et al. Internal Mammary and Medial Supraclavicular Irradiation in Breast Cancer. The New England Journal of Medicine. 2015;373(4):317–327.CrossRefGoogle Scholar
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    Whelan TJ, Olivotto IA, Parulekar WR, et al. Regional nodal irradiation in early-stage breast cancer. The New England Journal of Medicine. 2015;373(4):307–316.CrossRefGoogle Scholar
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    Bazan JG, Majithia L, Quick AM, et al. Heterogeneity in outcomes of pathologic T1-2N1 breast cancer after mastectomy: looking beyond locoregional failure rates. Ann Surg Oncol. 2018;25:2288–2295.CrossRefGoogle Scholar
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    Canadian Cancer Trials Group. Regional Radiotherapy in Biomarker Low Risk Node Positive Breast Cancer (TAILOR RT). identifier NCT03488693. Available at: Accessed 24 Sept 2018.

Copyright information

© Society of Surgical Oncology 2018

Authors and Affiliations

  1. 1.Department of Radiation Oncology, James Cancer HospitalThe Ohio State University Comprehensive Cancer CenterColumbusUSA

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