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Annals of Surgical Oncology

, Volume 26, Issue 2, pp 702–702 | Cite as

Reply to “Can Patients with Multiple Breast Cancers in the Same Breast Avoid Mastectomy by Having Multiple Lumpectomies to Achieve Equivalent Rates of Local Breast Cancer Recurrence? Response to the Preliminary Alliance 11102 Trial Report”

  • Kari M. RosenkranzEmail author
  • Karla Ballman
  • Linda McCall
  • Charlotte Dai Kubicky
  • Laurie Cuttino
  • Huong Le-Petross
  • Kelly Hunt
  • Armando Giuliano
  • Kimberly Van Zee
  • Bruce Haffty
  • Judy Boughey
Breast Oncology
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To the Editors

We thank Dr. Winters and Benson for their letter to the editor entitled “Can patients with multiple breast cancers in the same breast avoid mastectomy by having multiple lumpectomies to achieve equivalent rates of local regional recurrence? Response to the preliminary Alliance 11102 trial report”. The authors raise some important issues regarding long-term cosmetic outcome (particularly given the low utilization of oncoplastic techniques in our patient cohort) and the potential for long-term radiation complications, given the need for boost to two or three lumpectomy cavities. We agree wholeheartedly that these are potential issues for women undergoing breast-conserving therapy for multiple ipsilateral breast cancer (MIBC). Both of these planned secondary endpoints will be reported in the future. Additionally, we are evaluating the incidence of lymphedema and the primary endpoint of local recurrence in our patient population, which will also be reported in the future.

We acknowledge that the single-arm design may be a limitation in the final analysis of local recurrence rates. A randomized study would provide higher-level evidence and allow comparison of outcomes of breast conservation versus mastectomy in this population. However, it was felt that accrual to a randomized study would be challenging due to potential patient and/or surgeon preference. We congratulate Drs. Winters and Benson and colleagues on their upcoming randomized, prospective MIAMI trial, which evaluates the questions of feasibility and safety of breast conservation in MIBC in a cohort of 50 patients.

Copyright information

© Society of Surgical Oncology 2018

Authors and Affiliations

  • Kari M. Rosenkranz
    • 1
    Email author
  • Karla Ballman
    • 2
  • Linda McCall
    • 3
  • Charlotte Dai Kubicky
    • 4
  • Laurie Cuttino
    • 5
  • Huong Le-Petross
    • 6
  • Kelly Hunt
    • 7
  • Armando Giuliano
    • 8
  • Kimberly Van Zee
    • 9
  • Bruce Haffty
    • 9
  • Judy Boughey
    • 10
  1. 1.Dartmouth Hitchcock Medical CenterLebanonUSA
  2. 2.Division of Biostatistics and EpidemiologyWeill Cornell Medical CollegeNew York CityUSA
  3. 3.Alliance Statististics and Data CenterDuke Cancer InstituteDurhamUSA
  4. 4.Oregon Health and Science UniversityPortlandUSA
  5. 5.Virginia Commonwealth UniverstiyRichmondUSA
  6. 6.Diagnostic RadiologyUT MD Anderson Cancer CenterHoustonUSA
  7. 7.Department of Surgical OncologyUT MD Anderson Cancer CenterHoustonUSA
  8. 8.Surgical OncologyCedars-Sinai Medical CenterLos AngelesUSA
  9. 9.Radiation Oncology, Cancer Institute of New Jersey/Robert WoodJohnson University HospitalNew BrunswickUSA
  10. 10.Mayo ClinicRochesterUSA

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