Annals of Surgical Oncology

, Volume 25, Supplement 3, pp 816–817 | Cite as

ASO Author Reflections: Regulation of Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma by Vitamin D Supplementation

  • Yosuke Mukai
  • Hidetoshi EguchiEmail author
ASO Author Reflections



There are no conflicts of interest.


  1. 1.
    Sherman MH, Yu RT, Engle DD, et al. Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell. 2014;159(1):80–93.CrossRefPubMedCentralGoogle Scholar
  2. 2.
    Bachem MG, Schunemann M, Ramadani M, et al. Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells. Gastroenterology. 2005;128:907–21.CrossRefGoogle Scholar
  3. 3.
    Pietras K, Ostman A. Hallmarks of cancer: interactions with the tumor stroma. Exp Cell Res. 2010;316:1324–31.CrossRefGoogle Scholar
  4. 4.
    Pan B, Liao B, Niu Z, et al. Cancer-associated fibroblasts in pancreatic adenocarcinoma. Future Oncol. 2015;11:2603–10.CrossRefGoogle Scholar
  5. 5.
    Mukai Y, Yamada D, Eguchi H, et al. Vitamin D supplementation is a promising therapy for pancreatic ductal adenocarcinoma in conjunction with current chemoradiation therapy. Ann Surg Oncol. 2018;25:1868–79.CrossRefGoogle Scholar
  6. 6.
    Yamada D, Eguchi H, Iwagami Y, et al. Patients treated with preoperative chemoradiation for pancreatic ductal adenocarcinoma have impaired bone density, a predictor of distant metastasis. Ann Surg Oncol. 2017;24:3715–24.CrossRefGoogle Scholar

Copyright information

© Society of Surgical Oncology 2018

Authors and Affiliations

  1. 1.Department of Gastroenterological Surgery, Graduate School of MedicineOsaka UniversitySuitaJapan

Personalised recommendations