Advertisement

ASO Author Reflections: Do Distinct Patterns of Recurrence Impact the Prognosis of Patients With Resected Pancreatic Ductal Adenocarcinoma?

  • Vincent P. Groot
  • Christopher L. Wolfgang
  • Jin He
ASO Author Reflections

Past

For patients with localized pancreatic ductal adenocarcinoma (PDAC), a combination of resection and systemic therapy offers the best chance for long-term survival. However, even after completion of multimodality therapy, disease recurrence is common and is the foremost cause of disease-specific mortality. Recent evidence suggests that not all PDAC recurrences exhibit the same biological behavior. For instance, a recent study from our institution showed that post-recurrence survival differs based on the timing of recurrence.1 Furthermore, a different study found that the time to recurrence varies for distinct recurrence locations.2However, the relationship of these specific PDAC recurrence patterns with survival after recurrence and overall survival from surgery remains poorly described. Knowledge on the prognostic impact of distinct recurrence sites could aid clinicians with prognostic stratification, and might potentially provide a basis for a more individualized approach to...

Notes

Disclosure

Vincent P. Groot, Christopher L. Wolfgang, and Jin He have no financial disclosures or conflicts of interest to declare.

References

  1. 1.
    Groot VP, Gemenetzis G, Blair AB, et al. Defining and predicting early recurrence in 957 patients with resected pancreatic ductal adenocarcinoma. Ann Surg.  https://doi.org/10.1097/sla.0000000000002734 (Epub 23 Mar 2018).CrossRefPubMedGoogle Scholar
  2. 2.
    Groot VP, Rezaee N, Wu W, et al. Patterns, timing, and predictors of recurrence following pancreatectomy for pancreatic ductal adenocarcinoma. Ann Surg. 2018;267:936–45.PubMedGoogle Scholar
  3. 3.
    Groot VP, Gemenetzis G, Blair AB, et al. Implications of the pattern of disease recurrence on survival following pancreatectomy for pancreatic ductal adenocarcinoma. Ann Surg Oncol. 2018;25:2475–83.CrossRefGoogle Scholar
  4. 4.
    Arnaoutakis GJ, Rangachari D, Laheru DA, et al. Pulmonary resection for isolated pancreatic adenocarcinoma metastasis: an analysis of outcomes and survival. J Gastrointest Surg. 2011;15:1611–1617.CrossRefGoogle Scholar
  5. 5.
    Groot VP, van Santvoort HC, Rombouts SJE, et al. Systematic review on the treatment of isolated local recurrence of pancreatic cancer after surgery; re-resection, chemoradiotherapy and SBRT. HPB (Oxford). 2017;19:83–92.CrossRefGoogle Scholar
  6. 6.
    Ryan JF, Groot VP, Rosati LM, et al. Stereotactic body radiation therapy for isolated local recurrence after surgical resection of pancreatic ductal adenocarcinoma appears to be safe and effective. Ann Surg Oncol. 2018;25:280–89.CrossRefGoogle Scholar
  7. 7.
    Takeno A, Takemasa I, Seno S, et al. Gene expression profile prospectively predicts peritoneal relapse after curative surgery of gastric cancer. Ann Surg Oncol. 2010;17:1033–42.CrossRefGoogle Scholar

Copyright information

© Society of Surgical Oncology 2018

Authors and Affiliations

  • Vincent P. Groot
    • 1
    • 2
  • Christopher L. Wolfgang
    • 1
  • Jin He
    • 1
  1. 1.Department of Surgery, The Sol Goldman Pancreatic Cancer Research CenterThe Johns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Department of Surgery, UMC Utrecht Cancer CenterUniversity Medical Center UtrechtUtrechtThe Netherlands

Personalised recommendations