Annals of Surgical Oncology

, Volume 25, Issue 12, pp 3738–3739 | Cite as

ASO Author Reflections: Hypoxia-Induced PLOD2 Is a Key Regulator in Epithelial–Mesenchymal Transition and Chemoresistance in Biliary Tract Cancer

  • Yuichiro Okumura
  • Hidetoshi EguchiEmail author
ASO Author Reflections



The authors have no conflicts of interest to disclose.


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    Noda T, Yamamoto H, Takemasa I, et al. PLOD2 induced under hypoxia is a novel prognostic factor for hepatocellular carcinoma after curative resection. Liver Int. 2012;32:110–8.CrossRefGoogle Scholar
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    Okumura Y, Noda T, Eguchi H, et al. Hypoxia-induced PLOD2 is a key regulator in epithelial–mesenchymal transition and chemoresistance in biliary tract cancer. Ann Surg Oncol. 2018. Scholar
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    Fischer KR, Durrans A, Lee S, et al. Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance. Nature. 2015; 527:472–6.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Society of Surgical Oncology 2018

Authors and Affiliations

  1. 1.Department of Gastroenterological Surgery, Graduate School of MedicineOsaka UniversitySuitaJapan

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