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Table VIII The Independent Variables and Response Summary Obtained by Applying Full Factorial Design

From: Implementing the Design of Experiments (DoE) Concept into the Development Phase of Orodispersible Minitablets (ODMTs) Containing Melatonin

Trial number Independent variable (CPP) Dependent variables (CQA)
Main compression force (kN) Table speed (rpm) Resistance to crushing (N) Resistance to crushing SD1 Disintegration time (s) Weight SD1 Resistance to crushing TXT3 (N) Disintegration time TXT3 (s)
1 6.0 13 3.60 0.96 3.00 0.25 8.102 6.821
2 6.0 18 3.80 1.38 3.00 0.19 7.509 6.185
3 6.0 23 3.60 0.78 3.00 0.13 7.317 6.378
4 10.0 13 4.80 1.34 2.00 0.28 10.977 11.349
5 10.0 18 5.10 1.28 4.00 0.24 10.937 12.364
6 10.0 23 4.70 1.24 2.00 0.31 10.896 12.331
7 14.0 13 5.70 1.05 5.00 0.30 11.893 15.087
8 14.0 18 6.10 1.44 4.00 0.34 12.104 16.840
9 14.0 23 6.10 1.05 3.33 0.36 12.811 16.398
10C2 10.0 18 5.20 1.49 4.67 0.09 12.291 11.992
11C2 10.0 18 5.10 1.51 5.50 0.11 11.453 11.992
12C2 10.0 18 5.30 1.18 2.67 0.09 12.316 11.157
  1. 1SD standard deviation; 2C center point; 3TXT texture analysis