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Table VII The Independent Variables and Responses Summary Obtained from Compression Experiments Using 5-Tip Tools, Performed According to Placket-Burman Design

From: Implementing the Design of Experiments (DoE) Concept into the Development Phase of Orodispersible Minitablets (ODMTs) Containing Melatonin

Independent variables Dependent variables
Run no. Amount of punches Table speed (rpm) Feeder speed (rpm) Pre-compression force (kN) Main compression force (kN) Carrier type API type Blend uniformity RSD (%) Tablet weight spread (mg) API dissolution (%) after 15 min. Resistance to crushing (N) (mean ± SD) Resistance to crushing spread (N) Friability (%) Content uniformity (AV)
1 2 16 10 1.0 8 GFD Micronized 0.60 1.5 96.0 11.30 ± 0.75 4 0.52 2.7
2 2 16 15 1.0 2 GIQ Coarse 5.41 1.0 35.8 12.05 ± 0.80 11 0.30 18.1
3 2 25 10 0.5 8 GIQ Coarse 13.46 1.0 34.6 16.65 ± 0.98 11 0.49 19.5
4 2 25 15 0.5 2 GFD Micronized 1.04 0.6 95.3 5.37 ± 0.62 3 0.61 2.5
5 6 16 10 0.5 2 GFD Coarse 4.56 1.0 93.5 4.45 ± 0.51 3 0.68 21.9
6 6 16 15 0.5 8 GIQ Micronized 1.02 0.9 41.9 19.95 ± 3.05 16 0.37 6.2
7 6 25 10 1.0 2 GIQ Micronized 1.08 0.9 42.4 10.40 ± 1.18 12 0.19 21.4
8 6 25 15 1.0 8 GFD Coarse 5.56 1.4 87.0 9.00 ± 0.33 3 0.49 16.9