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Table V Particle Size Distribution and span Values of Melatonin and Carriers Determined with Laser Diffraction Method, Mean ± Standard Deviation, n=6

From: Implementing the Design of Experiments (DoE) Concept into the Development Phase of Orodispersible Minitablets (ODMTs) Containing Melatonin

Material d0.1 μm d0.5 μm d0.9 μm span
Micronized melatonin 0.12 ± 0.01 2.11 ± 0.27 5.75 ± 0.24 2.70 ± 0.28
Non-micronized melatonin 4.73 ± 0.24 30.86 ± 4.64 142.74 ± 17.78 4.55 ± 0.87
GalenIQTM 721 14.11 ± 0.53 61.90 ± 1.53 183.54 ± 9.42 2.74 ± 0.08
Granfiller-DTM 215 10.65 ± 0.16 55.79 ± 0.22 190.74 ± 1.35 3.23 ± 0.02